| Cat. No. |
Product Name |
Information |
| PC-28195 |
MM-401 TFA
MLL1/WDR5 inhibitor
|
MM-401 TFA is a potent inhibitor of MLL1/WDR5 protein-protein interaction with IC50 of 0.9 nM. |
| PC-28194 |
MS2928 TFA
SETD8 inhibitor
|
MS2928 TFA is a potent and selective SETD8 covalent inhibitor, inhibits SETD8 methyltransferase activity with IC50 of 0.14 uM, covalently modifies SETD8 at Cys311. |
| PC-28193 |
ND-L11B TFA
NSD2 degrader
|
ND-L11B TFA is an effective degrader of RE-IIBP and NSD2-long, effectively induces NSD2 degradation with DC50 of 1.48 and 0.80 uM in KMS11 MM cell line, reduces H3K36me2 level in cancer cells. |
| PC-28192 |
GSK2807 Trifluoroacetate
SMYD3 inhibitor
|
GSK2807 Trifluoroacetate (GSK 2807) is a potent and selective, SAM-competitive inhibitor of SMYD3 with Ki of 14 nM and IC50 of 130 nM. |
| PC-27907 |
AN-465 dihydrochloride
EV71 inhibitor, METTL3 inhibitor
|
AN-465 dihydrochloride (AN-465/42162872, AN465) is a potent inhibitor of Enterovirus 71 (EV71) with EC50 of 18.48 uM, effectively inhibits m6A methyltransferase METTL3 with IC50 of 1.782 uM and KD of 8.75 uM. |
| PC-27334 |
IGF2BP3-IN-2
IGF2BP3 inhibitor
|
IGF2BP3-IN-2 is a potent, selective small molecule inhibitor of RNA m6A reader insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) with IC50 of 0.12 uM in cellular thermal shift assay (CETSA). |
| PC-26565 |
GD433
NTMT1 inhibitor
|
GD433 is a potent, selective and substrate competitive inhibitor of N-terminal methyltransferase 1 (NTMT1) with IC50 of 27 nM. |
| PC-26383 |
(+)SHIN2
SHMT1/2 inhibitor
|
(+)SHIN2 is a folate-competitive, cell-permeable inhibitor of human SHMT1/2 with improved pharmacokinetic properties over SHIN1. |
| PC-26366 |
WDR5 oligomerization inducer WZ-1
WDR5 oligomerization inducer
|
WZ-1 is a selective WDR5 oligomerization inducer, binds the WBM site of WDR5 and reacts with Cys248 to form an intramolecular disulfide, triggers oligomerization via thio-disulfide exchange, disrupting WDR5 interactions at both WIN and WBM sites. |
| PC-25711 |
Heterochromatin protein 1 inhibitor (R)-18
HP1 inhibitor
|
Heterochromatin protein 1 inhibitor (R)-18 is a small-molecule inhibitor of heterochromatin protein 1 (HP1), inhibits the HP1/H3K9me3 interaction with IC50 of 18.1 uM. |
| PC-24895 |
KMT9 inhibitor 8
KMT9 inhibitor
|
KMT9 inhibitor 8 is the ethyl ester prodrug of KMT9 inhibitor 7b, a potent and selective lysine methyltransferase 9 (KMT9) inhibitor with Kd of 10 nM. |
| PC-23079 |
MS167
PRMT6 inhibitor
|
MS167 is a potent, selective and cell-active reversible PRMT6 inhibitor with IC50 of 28 nM. |
