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IGF2BP3-IN-2

Chemical Structure : IGF2BP3-IN-2

CAS No.: 3070282-89-9

IGF2BP3-IN-2

Catalog No.: PC-27334Not For Human Use, Lab Use Only.

IGF2BP3-IN-2 is a potent, selective small molecule inhibitor of RNA m6A reader insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) with IC50 of 0.12 uM in cellular thermal shift assay (CETSA).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

IGF2BP3-IN-2 is a potent, selective small molecule inhibitor of RNA m6A reader insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) with IC50 of 0.12 uM in cellular thermal shift assay (CETSA).

Physicochemical Properties

M.Wt 465.88
Formula C20H15ClF3N5OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(4-chloro-2-methyl-6-(trifluoromethyl)phenyl)-2-((8-methyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)thio)acetamide

References

1. Scherer GM, et al. J Med Chem. 2026 Jul 15. doi: 10.1021/acs.jmedchem.6c00965.

2. Patent WO2025024377 A1.

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