Heterochromatin protein 1 inhibitor (R)-18

Chemical Structure : Heterochromatin protein 1 inhibitor (R)-18

Catalog No.: PC-25711Not For Human Use, Lab Use Only.

Heterochromatin protein 1 inhibitor (R)-18 is a small-molecule inhibitor of heterochromatin protein 1 (HP1), inhibits the HP1/H3K9me3 interaction with IC50 of 18.1 uM.

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Biological Activity

Heterochromatin protein 1 inhibitor (R)-18 is a small-molecule inhibitor of heterochromatin protein 1 (HP1), inhibits the HP1/H3K9me3 interaction with IC50 of 18.1 uM.

Physicochemical Properties

M.Wt	340.38
Formula	C19H20N2O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-(4-nitrobenzyl)pyrrolidine

References

1. Tokuyama A, et al. Bioorg Med Chem Lett. 2025 Nov 9:130469.

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