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LC-YD03

Chemical Structure : LC-YD03

CAS No.:

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LC-YD03

Catalog No.: PC-27973Not For Human Use, Lab Use Only.

LC-YD03 is a potent, selective YTH domain-containing protein 1 (YTHDC1) inhibitor with IC50 of 41.98 nM and BLI Kd of 102 nM, shows little to no activity against YTHDF1, YTHDF2, YTHDF3, and YTHDC2.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

LC-YD03 is a potent, selective YTH domain-containing protein 1 (YTHDC1) inhibitor with IC50 of 41.98 nM and BLI Kd of 102 nM, shows little to no activity against YTHDF1, YTHDF2, YTHDF3, and YTHDC2.
LC-YD03 also shows no apparent off-target activity against METTL3/METTL14 or the tested kinase panel.
LC-YD03 retains activity against YTHDC1(WT), YTHDC1(N363A), and YTHDC1(S378A), with IC50 values of 290.7 nM, 396.9 nM, and 476.3 nM, respectively.

Physicochemical Properties

M.Wt 438.88
Formula C20H19ClN8O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

methyl 2-(4-((2-chloro-6-(methylamino)-9H-purin-9-yl)methyl)-1H-1,2,3-triazol-1-yl)-2,3-dihydro-1H-indene-2-carboxylate

References

1. Mingchen Wang, et al. Adv Sci (Weinh). 2026 Aug 27:e77386.

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