Chemical Structure : TRDMT1i
CAS No.:
2760719-98-8
TRDMT1i
(YW1842, YW-1842, TRDMT1 inhibitor)
Catalog No.: PC-28173Not For Human Use, Lab Use Only.
TRDMT1i (YW1842, YW-1842) is a potent small molecule inhibitor of RNA methyltransferase TRDMT1, blocks TRDMT1-mediated m5C formation in DNA-RNA hybrids in vitro and reduces the viability of cancer cell lines.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TRDMT1i (YW1842, YW-1842) is a potent small molecule inhibitor of RNA methyltransferase TRDMT1, blocks TRDMT1-mediated m5C formation in DNA-RNA hybrids in vitro and reduces the viability of cancer cell lines.
TRDMT1i (YW1842, YW-1842) exhibits -m5C inhibitory activity almost equivalent to TRDMT1 depletion at the concentration of 2.5 uM.
TRDMT1i (YW1842, YW-1842) specifically sensitizes cells to DNA damage agents in a TRDMT1-dependent manner.
TRDMT1i selectively induces synthetic lethality in MutLα-deficient cells, but not MutLβ and MutS-deficient cells.
TRDMT1i (100 or 200 mg/kg, oral gavage) inhibits growth of MLH1-deficient tumors in BALB/c mice bearing CT26 Mlh1-KO tumors.
Physicochemical Properties
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M.Wt
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492.57
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Formula
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C24H20N4O4S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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6,7-dimethoxy-2-(4-(4-(methylsulfonyl)phenyl)-1H-pyrazol-1-yl)-4-(thiophen-3-yl)quinazoline
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References
1. Xiaolan Zhu, et al. NAR Cancer. 2021 Mar 22;3(1):zcab010.
2. Ghosh A, et al. Nat Commun. 2026 Aug 10;17(1):9566.
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