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Cat. No. Product Name Information
PC-21348

Salvianolic acid C

YTHDF1 inhibitor

Salvianolic acid C (YTHDF1 inhibitor SAC) is a selective, competitive small molecule inhibitor of m6A reader YTHDF1 with IC50 of 1.4 uM in in vitro binding assays, shows weaker activity against YTHDF2 (IC50=29 uM), inhibits YTHDF1 and suppresses oligomerization of YTHDF1.
PC-21346

MS1262

G9a/GLP inhibitor

MS1262 is a highly potent, selective and brain-penetrant inhibitor of G9a/GLP methylase with IC50 of 19/6 nM, respectively.
PC-21038

KTX-1001

NSD2 inhibitor

KTX-1001 is a potent, selective histone methyltransferase NSD2 (WHSC1, MMSET) inhibitor targeting the catalytic SET domain.
PC-49859

DS-1594a

Menin-MLL1 inhibitor

DS-1594a (Emilumenib) is a highly potent Menin-MLL1 inhibitor with IC50 of 1.4 nM in cell-free AlphaLISA assays, displays selective growth inhibition against AML and ALL cells with MLL1-r or NPM1c.
PC-49813

EM127

SMYD3 inhibitor

EM127 is a potent, site-specific covalent, second-generation inhibitor of SMYD3 methyltransferase.
PC-49724

JS1310

PRMT7 inhibitor

JS1310 (JS-1310) is a specific small-molecule PRMT7 inhibitor with IC50 of 5 uM (human PRMT7), displays no acitivity against type I PRMTs (PRMT1, 3, 4, 6, and 8, IC50 >100 uM) or the type II PRMT5 (IC50=50 uM).
PC-49679

METTL3 inhibitor UZH2

METTL3 inhibitor

METTL3 inhibitor UZH2 is a potent, selective and cell-permeable RNA methyltransferase METTL3 inhibitor with IC50 of 5 nM in TR-FRET assays.
PC-49559

PRT382

PRMT5 inhibitor

PRT382 (PRT-382) is a potent, selective and SAM-competitive PRMT5 inhibitor with IC50 of 2.8 nM in filtration binding assays with recombinant human PRMT5/MEP50 and histone H2A as the protein substrate.
PC-49558

CWI1-2

IGF2BP2 inhibitor

CWI1-2 is a small molecule inhibitor of m6A reader IGF2BP2, shows promising anti-leukemia effects in vitro and in vivo.
PC-49393

EPIC-0412

HOTAIR-EZH2 inhibitor

EPIC-0412 is a small-molecule inhibitor that enhances the chemotherapeutic effect of temozolomide (TMZ) by acting on the p21-E2F1 DNA damage repair axis and ATF3-p-p65-MGMT axis.
PC-49209

UNC6934

NSD2-PWWP1 inhibitor

UNC6934 is a potent, selective chemical probe ligand targeting the N-terminal PWWP (PWWP1) domain of NSD2 with Kd value of 91 nM, selectively binds in the aromatic cage of NSD2-PWWP1, thereby disrupting its interaction with H3K36me2 nucleosomes.
PC-49020

TC-E 5003

PRMT1 inhibitor

TC-E 5003 is a selective inhibitor of arginine methyltransferase I (PRMT1) with IC50 of 1.5 uM, does not inhibit PRMT4 or the lysine methyltransferase Set7/9.

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