| Cat. No. |
Product Name |
Information |
| PC-21348 |
Salvianolic acid C
YTHDF1 inhibitor
|
Salvianolic acid C (YTHDF1 inhibitor SAC) is a selective, competitive small molecule inhibitor of m6A reader YTHDF1 with IC50 of 1.4 uM in in vitro binding assays, shows weaker activity against YTHDF2 (IC50=29 uM), inhibits YTHDF1 and suppresses oligomerization of YTHDF1. |
| PC-21346 |
MS1262
G9a/GLP inhibitor
|
MS1262 is a highly potent, selective and brain-penetrant inhibitor of G9a/GLP methylase with IC50 of 19/6 nM, respectively. |
| PC-21301 |
NSUN2 inhibitor MY-1B
NSUN2 inhibitor
|
NSUN2 inhibitor MY-1B is specific, covalent inhibitor of RNA methyltransferase NSUN2 (IC50=1.3 uM) that stereoselectively react with the catalytic C271, has IC50 of 2.4 uM in RNA methylation assays. |
| PC-21038 |
KTX-1001
NSD2 inhibitor
|
KTX-1001 is a potent, selective histone methyltransferase NSD2 (WHSC1, MMSET) inhibitor targeting the catalytic SET domain. |
| PC-21012 |
EML734
PRMT7/9 inhibitor
|
EML734 is a selective small molecule inhibitor of protein arginine methyltransferase isoforms, PRMT7 and PRMT9 with IC50 of 0.32 and 0.89 uM, respectively. |
| PC-20124 |
DC-PRC2in-01
EZH2-EED inhibitor
|
DC-PRC2in-01 is a small molecule PRC2 inhibitor targeting EZH2-EED interaction with affinity Kd of 4.56 uM, decreases global H3K27me3 levels in cancer cells. |
| PC-20002 |
UNC2327
PRMT3 inhibitor
|
UNC2327 (UNC-2327) is a potent, allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) with IC50 of 230 nM. |
| PC-49859 |
DS-1594a
Menin-MLL1 inhibitor
|
DS-1594a (Emilumenib) is a highly potent Menin-MLL1 inhibitor with IC50 of 1.4 nM in cell-free AlphaLISA assays, displays selective growth inhibition against AML and ALL cells with MLL1-r or NPM1c. |
| PC-49813 |
EM127
SMYD3 inhibitor
|
EM127 is a potent, site-specific covalent, second-generation inhibitor of SMYD3 methyltransferase. |
| PC-49729 |
BRD9539
G9a inhibitor
|
BRD9539 is a small molecule inhibitor of histone hethyltransferase of G9a (euchromatin histone methyltransferase 2, EHMT2) with IC50 of 6.3 uM. |
| PC-49728 |
UNC0642
G9a/GLP inhibitor
|
UNC0642 (UNC 0642) is a potent and selective G9a and GLP histone lysine methyltransferase inhibitor with IC50 of <2.5 nM. |
| PC-49724 |
JS1310
PRMT7 inhibitor
|
JS1310 (JS-1310) is a specific small-molecule PRMT7 inhibitor with IC50 of 5 uM (human PRMT7), displays no acitivity against type I PRMTs (PRMT1, 3, 4, 6, and 8, IC50 >100 uM) or the type II PRMT5 (IC50=50 uM). |
