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Cat. No. Product Name Information
PC-23026

NSD2 inhibitor 42

NSD2 inhibitor

NSD2 inhibitor 42 (W4275) is a potent, selective inhibitor of histone lysine methyltransferase NSD2 with IC50 of 17 nM.
PC-22670

Thiol methyltransferase inhibitor DCMB

METTL7A inhibitor

Thiol methyltransferase inhibitor DCMB is a small moelcule inhibitor of thiol methyltransferase (TMT) with IC50 of 1.17 uM for METTL7A (TMT1A).
PC-22438

DF-A7

YTHDF2 inhibitor

DF-A7 a specific small-molecule degrader/inhibitor of m6A reader YTHDF2 with IC50 of 50 nM in immunoblotting assays (HEK 293T cells), induces degradation of YTHDF2 without affecting the degradation of YTHDF1 and YTHDF3.
PC-22432

MS152

EHMT2/G9a inhibitor

MS152 is a potent, selective and brain penetrant EHMT2/G9a inhibitor with biochemical IC50 of 126 nM/76 nM, respectively.
PC-22135

AMG193

PRMT5 inhibitor

AMG193 (AMG-193) is a potent, selective and MTA-cooperative PRMT5 inhibitor with IC50 of 107 nM in MTAP deleted cells, binds to the PRMT5-MTA complex with an extremely high affinity (3.9 pM).
PC-21974

Bleximenib oxalate

menin-KMT2A inhibitor

Bleximenib oxalate (JNJ-75276617 oxalate) is a potent, selective and orally bioavailable protein-protein interaction inhibitor of the binding between menin and KMT2A, binds to the menin protein with IC50 of 0.1 nM (human menin) in FITC assays.
PC-21973

JNJ-75276617

menin-KMT2A inhibitor

JNJ-75276617 (Bleximenib) is a potent, selective and orally bioavailable protein-protein interaction inhibitor of the binding between menin and KMT2A, binds to the menin protein with IC50 of 0.1 nM (human menin) in FITC assays.
PC-21950

GSK343

EZH2 inhibitor

GSK343 is a highly potent, selective, SAM-competitive, and cell-active EZH2 inhibitor with IC50 of 4 nM and Kiapp of 1.2 nM.
PC-21857

BI-9321 trihydrochloride

NSD3 inhibitor

BI-9321 (BI 9321) trihydrochloride is a potent, selective and cellular active inhibitor of the NSD3-PWWP1 domain with SPR Kd of 166 nM.
PC-21842

GSK3368715 dihydrochloride

Type 1 PRMT inhibitor

GSK3368715 (EPZ019997, GSK-3368715) dihydrochloride is a potent, reversible and SAM uncompetitive type I PRMT inhibitor with Kiapp of 1.5 to 81 nM for PRMT1, 3, 4, 6, and 8.
PC-21606

KMI169

KMT9 inhibitor

KMI169 (KMI-169) is a potent and selective lysine methyltransferase 9 (KMT9) inhibitor with ITC Kd of 25 nM and enzymatic IC50 of 50 nM.
PC-21348

Salvianolic acid C

YTHDF1 inhibitor

Salvianolic acid C (YTHDF1 inhibitor SAC) is a selective, competitive small molecule inhibitor of m6A reader YTHDF1 with IC50 of 1.4 uM in in vitro binding assays, shows weaker activity against YTHDF2 (IC50=29 uM), inhibits YTHDF1 and suppresses oligomerization of YTHDF1.

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