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TC-E 5003

Chemical Structure : TC-E 5003

CAS No.: 17328-16-4

TC-E 5003 (TC-E5003)

Catalog No.: PC-49020Not For Human Use, Lab Use Only.

TC-E 5003 is a selective inhibitor of arginine methyltransferase I (PRMT1) with IC50 of 1.5 uM, does not inhibit PRMT4 or the lysine methyltransferase Set7/9.

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Biological Activity

TC-E 5003 is a selective inhibitor of arginine methyltransferase I (PRMT1) with IC50 of 1.5 uM, does not inhibit PRMT4 or the lysine methyltransferase Set7/9.
TC-E 5003 reduces the expression of inducible NO synthase (iNOS) and expressions of COX-2, TNF-α, IL-1β and IL-6 in RAW264.7 cells.
TC-E 5003 regulates LPS-induced AP-1 transcriptional activity by modulating the c-Jun gene expression.
TC-E 5003 downregulates the nuclear translocation of the nuclear factor (NF)-κB subunits p65 and p50 and AP-1 transcriptional factor c-Jun.
TC-E 5003 directly regulates c-Jun gene expression, and attenuates the activation of IκBα and Src in NF-κB signaling.

Physicochemical Properties

M.Wt 401.258
Formula C16H14Cl2N2O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N,N'-(sulfonylbis(4,1-phenylene))bis(2-chloroacetamide)

References

1. Eunji Kim, et al. Int J Mol Sci. 2020 Apr 26;21(9):3058.

2. Elisabeth-Maria Bissinger, et al. Bioorg Med Chem. 2011 Jun 15;19(12):3717-31.

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