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Chemical Structure : MI-3
CAS No.: 1271738-59-0
Catalog No.: PC-38602Not For Human Use, Lab Use Only.
MI-3 is a potent inhibitor of the interaction between menin-MLL with IC50 of 648 nM, binds to menin (Kd = 201 nM) and inhibits the menin-MLL-AF9 interaction in HEK293 cells without affecting protein levels of menin or MLL-AF9.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | Get quote |
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MI-3 is a potent inhibitor of the interaction between menin-MLL with IC50 of 648 nM, binds to menin (Kd = 201 nM) and inhibits the menin-MLL-AF9 interaction in HEK293 cells without affecting protein levels of menin or MLL-AF9.
MI-3 inhibits growth of mouse bone marrow cells (BMCs) expressing the Hoxa9 transformation-dependent MLL fusion proteins MLL-AF9 or MLL-ENL with IC50 of 5 uM for both.
MI-3 inhibits growth of human leukemia cell lines containing MLL translocations and decreases the expression of the transcription factors HOXA9, HOXA10, and MEIS1 in THP-1 cells.
| M.Wt | 375.553 | |
| Formula | C18H25N5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-[4-(4,5-dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)-thieno[2,3-d]pyrimidine |
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1. Jolanta Grembecka, et al. Nat Chem Biol. 2012 Jan 29;8(3):277-84.
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