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MI-3

Chemical Structure : MI-3

CAS No.: 1271738-59-0

MI-3 (Menin-MLL inhibitor MI-3)

Catalog No.: PC-38602Not For Human Use, Lab Use Only.

MI-3 is a potent inhibitor of the interaction between menin-MLL with IC50 of 648 nM, binds to menin (Kd = 201 nM) and inhibits the menin-MLL-AF9 interaction in HEK293 cells without affecting protein levels of menin or MLL-AF9.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MI-3 is a potent inhibitor of the interaction between menin-MLL with IC50 of 648 nM, binds to menin (Kd = 201 nM) and inhibits the menin-MLL-AF9 interaction in HEK293 cells without affecting protein levels of menin or MLL-AF9.
MI-3 inhibits growth of mouse bone marrow cells (BMCs) expressing the Hoxa9 transformation-dependent MLL fusion proteins MLL-AF9 or MLL-ENL with IC50 of 5 uM for both.
MI-3 inhibits growth of human leukemia cell lines containing MLL translocations and decreases the expression of the transcription factors HOXA9, HOXA10, and MEIS1 in THP-1 cells.

Physicochemical Properties

M.Wt 375.553
Formula C18H25N5S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-[4-(4,5-dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)-thieno[2,3-d]pyrimidine

References

1. Jolanta Grembecka, et al. Nat Chem Biol. 2012 Jan 29;8(3):277-84.

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