Catalog No.: PC-49393Not For Human Use, Lab Use Only.
EPIC-0412 is a small-molecule inhibitor that enhances the chemotherapeutic effect of temozolomide (TMZ) by acting on the p21-E2F1 DNA damage repair axis and ATF3-p-p65-MGMT axis.
EPIC-0412 is a small-molecule inhibitor that enhances the chemotherapeutic effect of temozolomide (TMZ) by acting on the p21-E2F1 DNA damage repair axis and ATF3-p-p65-MGMT axis.
EPIC-0412 physically interrupts the binding of HOTAIR and EZH2, leading to the upregulation of CDKN1A and BBC3, causing cell cycle arrest and apoptosis in GBM cells.
EPIC-0412 inhibits DNA damage response in GBM cells through the p21-E2F1 DNA damage repair axis.
EPIC-0412 epigenetically silences MGMT through its interaction with the ATF3-p-p65-HADC1 axis at the MGMT promoter region.
EPIC-0412 restored the TMZ sensitivity in GBM in vivo experiments.
