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Chemical Structure : EPIC-0412
Catalog No.: PC-49393Not For Human Use, Lab Use Only.
EPIC-0412 is a small-molecule inhibitor that enhances the chemotherapeutic effect of temozolomide (TMZ) by acting on the p21-E2F1 DNA damage repair axis and ATF3-p-p65-MGMT axis.
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EPIC-0412 is a small-molecule inhibitor that enhances the chemotherapeutic effect of temozolomide (TMZ) by acting on the p21-E2F1 DNA damage repair axis and ATF3-p-p65-MGMT axis.
EPIC-0412 physically interrupts the binding of HOTAIR and EZH2, leading to the upregulation of CDKN1A and BBC3, causing cell cycle arrest and apoptosis in GBM cells.
EPIC-0412 inhibits DNA damage response in GBM cells through the p21-E2F1 DNA damage repair axis.
EPIC-0412 epigenetically silences MGMT through its interaction with the ATF3-p-p65-HADC1 axis at the MGMT promoter region.
EPIC-0412 restored the TMZ sensitivity in GBM in vivo experiments.
| M.Wt | 423.387 | |
| Formula | C21H18F5N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhao J, et al. Neuro Oncol. 2022 Oct 22:noac242.
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