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CWI1-2

Chemical Structure : CWI1-2

CAS No.: 2408590-36-1

CWI1-2 (IGF2BP2 inhibitor)

Catalog No.: PC-49558Not For Human Use, Lab Use Only.

CWI1-2 is a small molecule inhibitor of m6A reader IGF2BP2, shows promising anti-leukemia effects in vitro and in vivo.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CWI1-2 is a small molecule inhibitor of m6A reader IGF2BP2, shows promising anti-leukemia effects in vitro and in vivo.
IGF2BP2 promotes AML development and self-renewal of leukemia stem/initiation cells by regulating expression of critical targets (e.g., MYC, GPT2, and SLC1A5) in the glutamine metabolism pathways in an m6A-dependent manner.
High expression of IGF2BP2 is observed in AML and associates with unfavorable prognosis.

Physicochemical Properties

M.Wt 519.77
Formula C22H17Cl3N6O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-N',N''-bis((E)-5-chloro-2-hydroxybenzylidene)-2-((Z)-5-chloro-2-hydroxybenzylidene)hydrazine-1-carbohydrazonhydrazide

References

1. Weng H, et al. Cancer Cell. 2022 Dec 12;40(12):1566-1582.e10.

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