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Chemical Structure : MS8511
Catalog No.: PC-47080Not For Human Use, Lab Use Only.
MS8511 is a first-in-class G9a/GLP covalent, irreversible inhibitor with IC50 of 100/140 nM respectively, displays improved potency in enzymatic and cellular assays compare with noncovalent G9a/GLP inhibitor UNC0642.
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MS8511 is a first-in-class G9a/GLP covalent, irreversible inhibitor with IC50 of 100/140 nM respectively, displays improved potency in enzymatic and cellular assays compare with noncovalent G9a/GLP inhibitor UNC0642.
MS8511 also displayed potential kinetic preference for covalently modifying G9a over GLP.
MS8511 is a useful chemical tool for studying the functional roles of G9a and GLP by covalently modifying and inhibiting these methyltransferases.
| M.Wt | 495.668 | |
| Formula | C28H41N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kwang-Su Park, et al. J Med Chem. 2022 Jun 28. doi: 10.1021/acs.jmedchem.2c00652.
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