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MS8511

Chemical Structure : MS8511

CAS No.: 2866408-21-9

MS8511 (MS 8511)

Catalog No.: PC-47080Not For Human Use, Lab Use Only.

MS8511 is a first-in-class G9a/GLP covalent, irreversible inhibitor with IC50 of 100/140 nM respectively, displays improved potency in enzymatic and cellular assays compare with noncovalent G9a/GLP inhibitor UNC0642.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MS8511 is a first-in-class G9a/GLP covalent, irreversible inhibitor with IC50 of 100/140 nM respectively, displays improved potency in enzymatic and cellular assays compare with noncovalent G9a/GLP inhibitor UNC0642.
MS8511 also displayed potential kinetic preference for covalently modifying G9a over GLP.
MS8511 is a useful chemical tool for studying the functional roles of G9a and GLP by covalently modifying and inhibiting these methyltransferases.

Physicochemical Properties

M.Wt 495.668
Formula C28H41N5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(4-((1-isopropylpiperidin-4-yl)amino)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-2-yl)acrylamide

References

1. Kwang-Su Park, et al. J Med Chem. 2022 Jun 28. doi: 10.1021/acs.jmedchem.2c00652.

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