Chemical Structure : SKLB-Y13
CAS No.:
SKLB-Y13
Catalog No.: PC-25345Not For Human Use, Lab Use Only.
SKLB-Y13 is the first, selective small-molecule inhibitor targeting of the YTHDF1 m6A-binding pocket with IC50 of 0.76 uM, has selectivity for YTHDF1 over YTH family proteins.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SKLB-Y13 is the first, selective small-molecule inhibitor targeting of the YTHDF1 m6A-binding pocket with IC50 of 0.76 uM, has selectivity for YTHDF1 over YTH family proteins.
SKLB-Y13 interacts with YTHDF1-specific residues Tyr397 and Trp470.
SKLB-Y13 disrupts YTHDF1-PRPF6 mRNA interaction in an m6A-dependent manner in cells, thereby impairing the translation of PRPF6 and inhibiting BC proliferation while promoting apoptosis.
SKLB-Y13 exerts anti-BC activity in vitro and in vivo by specifically inhibiting PRPF6 translation.
Physicochemical Properties
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M.Wt
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514.43
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Formula
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C23H21Cl2N7OS
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-((5-chloro-2-(1-methyl-1H-pyrazol-5-yl)pyrimidin-4-yl)amino)-6-(2-chlorobenzyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide
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References
1. Wu Y, et al. Angew Chem Int Ed Engl. 2025 Aug 19:e202509316.
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