Chemical Structure : DC2-C1
CAS No.:
DC2-C1
Catalog No.: PC-25924Not For Human Use, Lab Use Only.
DC2-C1 is a potent and cell-active inhibitor of RNA N6-methyladenosine recognition protein YTHDC2 with IC50 of 168 nM in FP assays, high selectivity over other YTH-domain proteins.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
DC2-C1 is a potent and cell-active inhibitor of RNA N6-methyladenosine recognition protein YTHDC2 with IC50 of 168 nM in FP assays, high selectivity over other YTH-domain proteins.
DC2-C1 exhibits a robust binding affinity with an equilibrium dissociation constant (KD) of 0.46 uM in ITC assays.
DC2-C1 markedly reduced YTHDC2-AMIGO2 mRNA binding in MH7A cells, substantially accelerated AMIGO2 mRNA degradation, substantially inhibited MH7A cell clonogenic potential.
DC2-C1 markedly suppressed the clonogenic potential and invasion in PANC-1 or MiaPACA-2 cells.
DC2-C1 induced a dose-dependent increase in ACC1, FASN, and SREBP-1C mRNA levels in HepG2 cells, with no effect on FZD7 and ID2 mRNA, which are targets of YTHDF1 and YTHDF2, respectively.
Physicochemical Properties
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M.Wt
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472.72
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Formula
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C22H15BrClNO4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(5-bromo-3-chloro-2-hydroxyphenyl)-2-(11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetamide
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References
1. Yang Z, et al. Nat Commun. 2026 Jan 6;17(1):46.
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