| Cat. No. |
Product Name |
CAS No. |
Information |
| PC-43380 |
Cobimetinib R-enantiomer
|
934660-94-3 |
Cobimetinib R-enantiomer (GDC-0973. |
| PC-43369 |
Cobimetinib
|
934660-93-2 |
Cobimetinib (GDC-0973, XL-518) is a potent, selective MEK inhibitor with IC50 of 4.2 nM for MEK1. |
| PC-42857 |
AS703026
|
1236699-92-5 |
AS703026 (Pimasertib, MSC1936369B) is a potent, selective, allosteric, orally bioavailable MEK1/2 inhibitor, inhibits the growth of MM cell lines with IC50 of 0.005-2 uM. |
| PC-62664 |
Vacquinol-1
|
5428-80-8 |
Vacquinol-1 (NSC 13316) is a MKK4 (MAP2K4, MEK4) activator that induces vacuolization, induces ATP depletion in glioblastoma cells (IC50 = 3.14 uM) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells. |
| PC-45504 |
RO-5126766
|
946128-88-7 |
RO-5126766 (CH-5126766, Avutometinib) is a potent, first-in-class dual Raf/MEK inhibitor with IC50 of 56 nM/160 nM for C-Raf/MEK1. |
| PC-38495 |
(R)-STU104
|
1983136-72-6 |
(R)-STU104 is a potent, first-in-class TAK1-MKK3 porotein-protein interaction (PPI) inhibitor with SPR Kd of 71 nM for binding MKK3, disrupting the TAK1 phosphorylating MKK3. |
| PC-38429 |
Zapnometinib
|
303175-44-2 |
Zapnometinib (ATR-002, PD0184264) is the active metabolite of CI-1040, a novel MEK inhibitor (IC50=30.96 nM, cell free assay) with broad antiviral activity against different influenza virus strains, as well as SARS-CoV-2. |
