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Cat. No. Product Name CAS No. Information
PC-43380

Cobimetinib R-enantiomer

934660-94-3 Cobimetinib R-enantiomer (GDC-0973.
PC-43369

Cobimetinib

934660-93-2 Cobimetinib (GDC-0973, XL-518) is a potent, selective MEK inhibitor with IC50 of 4.2 nM for MEK1.
PC-42857

AS703026

1236699-92-5 AS703026 (Pimasertib, MSC1936369B) is a potent, selective, allosteric, orally bioavailable MEK1/2 inhibitor, inhibits the growth of MM cell lines with IC50 of 0.005-2 uM.
PC-62664

Vacquinol-1

5428-80-8 Vacquinol-1 (NSC 13316) is a MKK4 (MAP2K4, MEK4) activator that induces vacuolization, induces ATP depletion in glioblastoma cells (IC50 = 3.14 uM) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells.
PC-45504

RO-5126766

946128-88-7 RO-5126766 (CH-5126766, Avutometinib) is a potent, first-in-class dual Raf/MEK inhibitor with IC50 of 56 nM/160 nM for C-Raf/MEK1.
PC-38495

(R)-STU104

1983136-72-6 (R)-STU104 is a potent, first-in-class TAK1-MKK3 porotein-protein interaction (PPI) inhibitor with SPR Kd of 71 nM for binding MKK3, disrupting the TAK1 phosphorylating MKK3.
PC-38429

Zapnometinib

303175-44-2 Zapnometinib (ATR-002, PD0184264) is the active metabolite of CI-1040, a novel MEK inhibitor (IC50=30.96 nM, cell free assay) with broad antiviral activity against different influenza virus strains, as well as SARS-CoV-2.

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