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Zapnometinib

Chemical Structure : Zapnometinib

CAS No.: 303175-44-2

Zapnometinib (ATR-002, PD0184264)

Catalog No.: PC-38429Not For Human Use, Lab Use Only.

Zapnometinib (ATR-002, PD0184264) is the active metabolite of CI-1040, a novel MEK inhibitor (IC50=30.96 nM, cell free assay) with broad antiviral activity against different influenza virus strains, as well as SARS-CoV-2.

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Biological Activity

Zapnometinib (ATR-002, PD0184264) is the active metabolite of CI-1040, a novel MEK inhibitor (IC50=30.96 nM, cell free assay) with broad antiviral activity against different influenza virus strains, as well as SARS-CoV-2.
Zapnometinib (ATR-002, PD0184264) inhibits ERK-phosphorylation in human PBMCs and intracellular deposition.
Zapnometinib (ATR-002, PD0184264) exhibited antiviral effect against H1N1pdm09 or the H3N2 strain and on MDCK II cells with EC50 of 4.190-6.356 uM.
Zapnometinib (ATR-002, PD0184264) also efficiently blocks SARS-CoV-2 propagation and alleviates pro-inflammatory cytokine/chemokine responses.

Physicochemical Properties

M.Wt 409.555
Formula C13H7ClF2INO2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(2-Chloro-4-iodo-phenylamino)-3,4-difluoro benzoic acid

References

1. Bruchhagen C, et al. Sci Rep. 2018 Jun 14;8(1):9114.

2. Laure M, et al. Antiviral Res. 2020 Jun;178:104806.

3. Hamza H, et al. Front Microbiol. 2021 Feb 12;12:611958.

4. Schreiber A, et al. Cell Mol Life Sci. 2022 Jan 10;79(1):65.

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