Chemical Structure : Zapnometinib
CAS No.: 303175-44-2
Catalog No.: PC-38429Not For Human Use, Lab Use Only.
Zapnometinib (ATR-002, PD0184264) is the active metabolite of CI-1040, a novel MEK inhibitor (IC50=30.96 nM, cell free assay) with broad antiviral activity against different influenza virus strains, as well as SARS-CoV-2.
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Zapnometinib (ATR-002, PD0184264) is the active metabolite of CI-1040, a novel MEK inhibitor (IC50=30.96 nM, cell free assay) with broad antiviral activity against different influenza virus strains, as well as SARS-CoV-2.
Zapnometinib (ATR-002, PD0184264) inhibits ERK-phosphorylation in human PBMCs and intracellular deposition.
Zapnometinib (ATR-002, PD0184264) exhibited antiviral effect against H1N1pdm09 or the H3N2 strain and on MDCK II cells with EC50 of 4.190-6.356 uM.
Zapnometinib (ATR-002, PD0184264) also efficiently blocks SARS-CoV-2 propagation and alleviates pro-inflammatory cytokine/chemokine responses.
M.Wt | 409.555 | |
Formula | C13H7ClF2INO2 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
2-(2-Chloro-4-iodo-phenylamino)-3,4-difluoro benzoic acid |
1. Bruchhagen C, et al. Sci Rep. 2018 Jun 14;8(1):9114.
2. Laure M, et al. Antiviral Res. 2020 Jun;178:104806.
3. Hamza H, et al. Front Microbiol. 2021 Feb 12;12:611958.
4. Schreiber A, et al. Cell Mol Life Sci. 2022 Jan 10;79(1):65.
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