DK2403 | MAP2K7 (MEK7) inhibitor | Probechem Biochemicals

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Chemical Structure : DK2403

DK2403 (DK-2403, DK 2403)

Catalog No.: PC-20654Not For Human Use, Lab Use Only.

DK2403 (DK-2403) is a highly potent, selective and covalent MAP2K7 (MEK7) inhibitor with IC50 of 10 nM, covalently engages the unique Cys218 residue within the active site.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DK2403 (DK-2403) is a highly potent, selective and covalent MAP2K7 (MEK7) inhibitor with IC50 of 10 nM, covalently engages the unique Cys218 residue within the active site.
DK2403 (5-10 uM) decreased phosphorylation of JNK and ATF2 in T-ALL cells.
DK2403 showed virtually no activity against MEK4 (IC50 > 80 uM), and no appreciable activity on MEK1/2, p38α/β, or JNK1/2/3.
DK2403 displays potent and marked cytotoxicity in a variety of T-ALL cell lines (RPMI-8402 cell IC50=2.9 uM; ALL-SIL, IC50=1.1 uM).

Physicochemical Properties

M.Wt	368.82
Formula	C19H17ClN4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(NC1=CC=CC(OC2=NC=NC(NCC3=CC=CC=C3)=C2)=C1)CCl

References

1. Dalton R. Kim, et al. ACS Med. Chem. Lett. April 17, 2023.

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DK2403 (DK-2403, DK 2403)

Biological Activity

Physicochemical Properties

References

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