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DK2403

Chemical Structure : DK2403

CAS No.: 2902651-64-1

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DK2403 (DK-2403, DK 2403)

Catalog No.: PC-20654Not For Human Use, Lab Use Only.

DK2403 (DK-2403) is a highly potent, selective and covalent MAP2K7 (MEK7) inhibitor with IC50 of 10 nM, covalently engages the unique Cys218 residue within the active site.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DK2403 (DK-2403) is a highly potent, selective and covalent MAP2K7 (MEK7) inhibitor with IC50 of 10 nM, covalently engages the unique Cys218 residue within the active site.
    DK2403 (5-10 uM) decreased phosphorylation of JNK and ATF2 in T-ALL cells.
    DK2403 showed virtually no activity against MEK4 (IC50 > 80 uM), and no appreciable activity on MEK1/2, p38α/β, or JNK1/2/3.
    DK2403 displays potent and marked cytotoxicity in a variety of T-ALL cell lines (RPMI-8402 cell IC50=2.9 uM; ALL-SIL, IC50=1.1 uM).

    Physicochemical Properties

    M.Wt 368.82
    Formula C19H17ClN4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(3-((6-(benzylamino)pyrimidin-4-yl)oxy)phenyl)-2-chloroacetamide

    References

    1. Dalton R. Kim, et al. ACS Med. Chem. Lett. April 17, 2023.

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