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Chemical Structure : DK2403
Catalog No.: PC-20654Not For Human Use, Lab Use Only.
DK2403 (DK-2403) is a highly potent, selective and covalent MAP2K7 (MEK7) inhibitor with IC50 of 10 nM, covalently engages the unique Cys218 residue within the active site.
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DK2403 (DK-2403) is a highly potent, selective and covalent MAP2K7 (MEK7) inhibitor with IC50 of 10 nM, covalently engages the unique Cys218 residue within the active site.
DK2403 (5-10 uM) decreased phosphorylation of JNK and ATF2 in T-ALL cells.
DK2403 showed virtually no activity against MEK4 (IC50 > 80 uM), and no appreciable activity on MEK1/2, p38α/β, or JNK1/2/3.
DK2403 displays potent and marked cytotoxicity in a variety of T-ALL cell lines (RPMI-8402 cell IC50=2.9 uM; ALL-SIL, IC50=1.1 uM).
| M.Wt | 368.82 | |
| Formula | C19H17ClN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dalton R. Kim, et al. ACS Med. Chem. Lett. April 17, 2023.
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