| Cat. No. |
Product Name |
Information |
| PC-38429 |
Zapnometinib
MEK inhibitor
|
Zapnometinib (ATR-002, PD0184264) is the active metabolite of CI-1040, a novel MEK inhibitor (IC50=30.96 nM, cell free assay) with broad antiviral activity against different influenza virus strains, as well as SARS-CoV-2. |
| PC-38424 |
Tunlametinib
MEK inhibitor
|
Tunlametinib (HL-085) is a highly selective and potent MEK inhibitor with IC50 of 1.9 nM (MEK1), exhibits potent activity against RAS/RAF mutant cancer cells. |
| PC-38417 |
BT2
Angiogenesis inhibitor
|
BT2 is a thermostable small-molecule inhibitor of vascular permeability and angiogenesis, interacts with MEK1 and inhibits ERK phosphorylation, FosB/ΔFosB, and VCAM-1 expression. |
| PC-73276 |
INR119
MEK1/2 inhibitor
|
INR119 is a small molecule allosteric MAPKK (MAP2K, MEK1/2) inhibitor, binds fission yeast homologue Wis1 near C458 and protects Wis1 from inactivation by low levels of H2O2 in vitro. |
| PC-73145 |
GDC-0623
MEK1 inhibitor
|
GDC-0623 (RG 7421) is a potent, selective, ATP-uncompetitive inhibitor of MEK1 (Ki=0.13 nM). |
| PC-72995 |
URML-3881
MEK inhibitor
|
URML-3881 (URML3881) is a potent, specific MEK1/2 inhibitor IC50 of 30 nM in a cell-free kinase inhibition assay. |
| PC-72697 |
MAP855
MEK1/2 inhibitor
|
MAP855 (MAP-855) is a highly potent, selective, ATP-competitive MEK1/2 inhibitor (pERK IC50=5 nM) with equipotent inhibition of WT and mutant MEK1/2. |
| PC-72696 |
DTP3
MKK7 inhibitor
|
DTP3 (MKK7 inhibitor DTP3) is a specific D-tripeptide that disrupts the GADD45β/MKK7 complex (Kd=64.8 nM), kills MM cells effectively, and lacks toxicity to normal cells. |
| PC-72695 |
MEK4 inhibitor 6ff
MEK4 inhibitor
|
MEK4 inhibitor 6ff is potent, selective MEK4 inhibitor with IC50 of 66 nM. |
| PC-72692 |
MEK4 inhibitor 15o
MEK4 inhibitor
|
MEK4 inhibitor 15o is potent, selective, cell permeable MEK4 inhibitor with IC50 of 83 nM. |
| PC-72689 |
MEK4 inhibitor 10e
MEK4 inhibitor
|
MEK4 inhibitor 10e is potent, selective cell permeable MEK4 inhibitor with IC50 of 61 nM. |
| PC-38277 |
BSJ-04-122
MKK4/7 inhibitor
|
BSJ-04-122 is a potent, selective, covalent dual MKK4/7 inhibitor with IC50 of 4/181 nM, displays excellent kinome selectivity. |
