MEK4 inhibitor 15o

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Chemical Structure : MEK4 inhibitor 15o

Catalog No.: PC-72692Not For Human Use, Lab Use Only.

MEK4 inhibitor 15o is potent, selective, cell permeable MEK4 inhibitor with IC50 of 83 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MEK4 inhibitor 15o is potent, selective, cell permeable MEK4 inhibitor with IC50 of 83 nM.
MEK4 inhibitor 10e demonstrated significant reduction of phospho-JNK and antiproliferative properties against pancreatic cancer cell lines, molecular inhibition of MEK4 pathway activates the MEK1/2 pathway.
MEK4 inhibitor 10e demonstrated synergistic effects against pancreatic cancer cells with the combination of MEK1/2 inhibitors.

Physicochemical Properties

M.Wt	410.423
Formula	C20H15FN4O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((3-(6-fluoro-1H-indazol-3-yl)phenyl)sulfonamido)benzamide

References

1. Kwong AJ, et al. ACS Med Chem Lett. 2021 Sep 15;12(10):1559-1567.

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