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MKK7-COV-13

Chemical Structure : MKK7-COV-13

CAS No.: 2283355-66-6

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MKK7-COV-13 (MKK7 Covalent inhibitor 13)

Catalog No.: PC-35804Not For Human Use, Lab Use Only.

MKK7-COV-13 (MKK7 Covalent inhibitor 13) is a potent, selective, covalent MKK7 (MAP2K7) inhibitor with in vitro IC50 of 10 nM, displays >1,000-fold selectivity over MKK4 (IC50>10 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MKK7-COV-13 (MKK7 Covalent inhibitor 13) is a potent, selective, covalent MKK7 (MAP2K7) inhibitor with in vitro IC50 of 10 nM, displays >1,000-fold selectivity over MKK4 (IC50>10 uM).
    MKK7-COV-13 shows EC50 of 0.3-1.0 uM for reduction of p-JNK in HEK293 cell line, without effect on p-ERK levels at 10 uM.
    MKK7-COV-13 displays remarkable selectivity against a kinome panel of 76 kinases.
    MKK7-COV-13 inhibits the CD86+ response in primary mouse B cells in response to LPS stimulation.
     

    Physicochemical Properties

    M.Wt 342.196
    Formula C16H12BrN3O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(3-(6-bromo-1H-indazol-3-yl)phenyl)acrylamide

    References

    1. Shraga A, et al. Cell Chem Biol. 2018 Oct 24. pii: S2451-9456(18)30344-1.

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