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Chemical Structure : MKK7-COV-13
Catalog No.: PC-35804Not For Human Use, Lab Use Only.
MKK7-COV-13 (MKK7 Covalent inhibitor 13) is a potent, selective, covalent MKK7 inhibitor with in vitro IC50 of 10 nM, displays >1,000-fold selectivity over MKK4 (IC50>10 uM).
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MKK7-COV-13 (MKK7 Covalent inhibitor 13) is a potent, selective, covalent MKK7 inhibitor with in vitro IC50 of 10 nM, displays >1,000-fold selectivity over MKK4 (IC50>10 uM).
MKK7-COV-13 shows EC50 of 0.3-1.0 uM for reduction of p-JNK in HEK293 cell line, without effect on p-ERK levels at 10 uM.
MKK7-COV-13 displays remarkable selectivity against a kinome panel of 76 kinases.
MKK7-COV-13 inhibits the CD86+ response in primary mouse B cells in response to LPS stimulation.
| M.Wt | 342.196 | |
| Formula | C16H12BrN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shraga A, et al. Cell Chem Biol. 2018 Oct 24. pii: S2451-9456(18)30344-1.
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