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Chemical Structure : MMK7 inhibitor 4a
Catalog No.: PC-36064Not For Human Use, Lab Use Only.
MMK7 inhibitor 4a is a potent, sepecific, covalent inhibitor of MMK7 with IC50 of 10 nM, displays >800-fold selectivity over EGFR-WT and EGFR-L858R/T790M.
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MMK7 inhibitor 4a is a potent, sepecific, covalent inhibitor of MMK7 with IC50 of 10 nM, displays >800-fold selectivity over EGFR-WT and EGFR-L858R/T790M.
MMK7 inhibitor 4a formed a covalent bond to Cys218 at the end of the hinge region of MMK7.
MMK7 inhibitor 4a displayed an excellent selectivity profile at 1 uM against a panel of 320 kinases.
MMK7 inhibitor 4a potently inhibits cellular JNK at 1 uM and completely inhibited its downstream effector c-Jun with no effect on the JNK-pathway.
MMK7 inhibitor 4a is a valuable probe for further investigation to elucidate the function of MKK7 in cellular studies and in vivo.
| M.Wt | 457.50 | |
| Formula | C23H23N9O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wolle P, et al. J Med Chem. 2019 Feb 15. doi: 10.1021/acs.jmedchem.9b00102.
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