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Cat. No. Product Name Information
PC-62295

G573

MEK inhibitor

G 573 is a potent and selective, allosteric inhibitor of MEK with Ki of 0.3 nM.
PC-60589

PD184161

MEK1/2 inhibitor

PD184161 is a potent, orally-active MEK1/2 inhibitor with IC50 of 10-100 nM.
PC-42216

APS-2-79 hydrochloride

KSR-MEK inhibitor

APS-2-79 hydrochloride is a small molecule compound that modulates KSR-dependent MAPK signalling by antagonizing RAF heterodimerization, and the conformational changes required for phosphorylation and activation of KSR-bound MEK (KSR2 IC50=120 nM).
PC-42215

APS-2-79

KSR-MEK inhibitor

APS-2-79 is a small molecule compound that modulates KSR-dependent MAPK signalling by antagonizing RAF heterodimerization, and the conformational changes required for phosphorylation and activation of KSR-bound MEK (KSR2 IC50=120 nM).
PC-42489

PD0325901

MEK inhibitor

PD0325901 is a selective, non ATP-competitive MEK inhibitor with IC50 of 0.33 nM.
PC-44028

Refametinib

MEK1/2 inhibitor

Refametinib (BAY 86-97661, RDEA-119) is a potent, non-ATP-competitive, highly selective, allosteric inhibitor of MEK1/2 with IC50 of 19/47 nM respectively.
PC-45504

RO-5126766

Raf/MEK inhibitor

RO-5126766 (CH-5126766, Avutometinib, VS-6766) is a potent, first-in-class dual Raf/MEK inhibitor with IC50 of 56 nM/160 nM for C-Raf/MEK1.
PC-45828

PD-184352

MEK1/2 inhibitor

PD-184352 (CI-1040) is a potent, ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, displays 100-fold more selective for MEK1/2 than MEK5.
PC-42774

Trametinib

MEK1/2 inhibitor

Trametinib (GSK-1120212, JTP 74057) is a potent and highly specific MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM.
PC-44036

RO4987655

MEK inhibitor

RO4987655 (CH4987655, RG-7167) is a potent and highly selective small-molecule MEK inhibitor with IC50 of 5.2 nM.
PC-45572

BI-847325

MEK/Aurora inhibitor

BI-847325 is a potent, ATP-competitive MEK/Aurora kinase inhibitor, inhibts human Aurora A (IC50=25 nM) and Aurora C (IC50=16 nM).
PC-45849

Selumetinib

MEK inhibitor

Selumetinib (ARRY-142886, AZD-6244) highly potent and selective, ATP-uncompetitive inhibitor of MEK1/2 with IC50/Ki of 14.1 nM/22.6 nM for MEK1.

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