| Cat. No. |
Product Name |
Information |
| PC-42877 |
PD318088
MEK1/2 inhibitor
|
PD318088 is a potent, non-ATP competitive, allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site. |
| PC-42872 |
AZD8330
MEK1/2 inhibitor
|
AZD8330 (ARRY-424704, ARRY-704) is a potent, selective, non-ATP competitive MEK1/2 inhibitor with IC50 of 7 nM. |
| PC-42870 |
BIX02189
MEK5/ERK5 inhibitor
|
BIX02189 is a potent, selective inhibitor of MEK5 catalytic activity with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity (IC50=59 nM), does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2. |
| PC-42857 |
AS703026
MEK1/2 inhibitor
|
AS703026 (Pimasertib, MSC1936369B) is a potent, selective, allosteric, orally bioavailable MEK1/2 inhibitor, inhibits the growth of MM cell lines with IC50 of 0.005-2 uM. |
| PC-42845 |
U0126
MEK inhibitor
|
U0126 (U0126-EtOH) is a potent, selective MEK (MAP2K) inhibitor with IC50 of 70 nM and 60 nM for MEK1 and MEK2, suppresses AP-1-mediated gene activation in transient transfection assays with IC50 of 0.96 uM. |
| PC-42842 |
PD98059
MEK inhibitor
|
PD98059 (PD 098059) is a specific MEK inhibitor with IC50 of ~10 uM without significant inhibitory activity of MAPK. |
| PC-62664 |
Vacquinol-1
MKK4 activator
|
Vacquinol-1 (NSC 13316) is a MKK4 (MAP2K4, MEK4) activator that induces vacuolization, induces ATP depletion in glioblastoma cells (IC50 = 3.14 uM) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells. |
| PC-62537 |
EBI-1051
MEK1 inhibitor
|
EBI-1051 is a novel and orally efficacious MEK inhibitor with IC50 of 10.8 nM against MEK1, inhibits viability of colo-205 cells with IC50 of 4.7 nM. |
| PC-62503 |
E6201
MEK1/MEKK1 inhibitor
|
E 6201 (ER-806201) is a potent, selective, dual MEK1 and MEKK1 inhibitor, inhibits LPS-induced TNFα transcription with IC50 of 50 nM. |
| PC-62295 |
G573
MEK inhibitor
|
G 573 is a potent and selective, allosteric inhibitor of MEK with Ki of 0.3 nM. |
| PC-60589 |
PD184161
MEK1/2 inhibitor
|
PD184161 is a potent, orally-active MEK1/2 inhibitor with IC50 of 10-100 nM. |
| PC-42216 |
APS-2-79 hydrochloride
KSR-MEK inhibitor
|
APS-2-79 hydrochloride is a small molecule compound that modulates KSR-dependent MAPK signalling by antagonizing RAF heterodimerization, and the conformational changes required for phosphorylation and activation of KSR-bound MEK (KSR2 IC50=120 nM). |
