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PD98059

Chemical Structure : PD98059

CAS No.: 167869-21-8

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PD98059 (PD 098059, PD-98059)

Catalog No.: PC-42842Not For Human Use, Lab Use Only.

PD98059 (PD 098059) is a specific MEK inhibitor with IC50 of ~10 uM without significant inhibitory activity of MAPK.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PD98059 (PD 098059) is a specific MEK inhibitor with IC50 of ~10 uM without significant inhibitory activity of MAPK.
PD98059 prevents activation of MAPK and subsequent phosphorylation of MAPK substrates both in vitro and in intact cells.

Physicochemical Properties

M.Wt 267.2793
Formula C16H13NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 16 mg/mL; H2O: < 0.01 mg/mL
Chemical Name/SMILES

4H-1-Benzopyran-4-one, 2-(2-amino-3-methoxyphenyl)-

References

1. Dudley DT, et al. Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7686-9.

2. Alessi DR, et al. J Biol Chem. 1995 Nov 17;270(46):27489-94.

3. Simon C, et al. Br J Cancer. 1999 Jul;80(9):1412-9.

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