Vacquinol-1 |CAS:5428-80-8 Probechem Biochemicals

Chemical Structure : Vacquinol-1

CAS No.: 5428-80-8

Vacquinol-1 (NSC13316, NSC 13316)

Catalog No.: PC-62664Not For Human Use, Lab Use Only.

Vacquinol-1 (NSC 13316) is a MKK4 (MAP2K4, MEK4) activator that induces vacuolization, induces ATP depletion in glioblastoma cells (IC50 = 3.14 uM) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells.

Packing	Price	Stock
5 mg	$128	In stock
10 mg	$188	In stock
25 mg	$328	In stock
50 mg	$528	In stock
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Biological Activity

Vacquinol-1 (NSC 13316) is a MKK4 (MAP2K4, MEK4) activator that induces vacuolization, induces ATP depletion in glioblastoma cells (IC50 = 3.14 uM) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells.
Vacquinol-1 induces rapid and specific cell death of glioma cells via membrane ruffling, cell rounding, massive macropinocytic vacuole accumulation, ATP depletion, and cytoplasmic membrane rupture.
Vacquinol-1 shows good brain penetrance and excellent pharmacokinetics; orally bioactive.

Physicochemical Properties

M.Wt	352.862
Formula	C21H21ClN2O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	[2-(4-Chlorophenyl)quinolin-4-yl](piperidine-2-yl)methanol

References

1. Kitambi SS, et al. Cell. 2014 Apr 10;157(2):313-28.

2. Hammarström LG, et al. J Med Chem. 2016 Sep 22;59(18):8577-92.

3. Sander P, et al. Oncotarget. 2017 May 23;8(21):35124-35137.

Vacquinol-1 (NSC13316, NSC 13316)

Biological Activity

Physicochemical Properties

References

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