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Chemical Structure : Vacquinol-1
CAS No.: 5428-80-8
Catalog No.: PC-62664Not For Human Use, Lab Use Only.
Vacquinol-1 (NSC 13316) is a MKK4 (MAP2K4, MEK4) activator that induces vacuolization, induces ATP depletion in glioblastoma cells (IC50 = 3.14 uM) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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Vacquinol-1 (NSC 13316) is a MKK4 (MAP2K4, MEK4) activator that induces vacuolization, induces ATP depletion in glioblastoma cells (IC50 = 3.14 uM) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells.
Vacquinol-1 induces rapid and specific cell death of glioma cells via membrane ruffling, cell rounding, massive macropinocytic vacuole accumulation, ATP depletion, and cytoplasmic membrane rupture.
Vacquinol-1 shows good brain penetrance and excellent pharmacokinetics; orally bioactive.
| M.Wt | 352.862 | |
| Formula | C21H21ClN2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
[2-(4-Chlorophenyl)quinolin-4-yl](piperidine-2-yl)methanol |
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1. Kitambi SS, et al. Cell. 2014 Apr 10;157(2):313-28.
2. Hammarström LG, et al. J Med Chem. 2016 Sep 22;59(18):8577-92.
3. Sander P, et al. Oncotarget. 2017 May 23;8(21):35124-35137.
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