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Chemical Structure : Cobimetinib
CAS No.: 934660-93-2
Catalog No.: PC-43369Not For Human Use, Lab Use Only.
Cobimetinib (GDC-0973, XL518) is a potent, selective MEK inhibitor with IC50 of 4.2 nM for MEK1.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | $428 | In stock | |
| 250 mg | Get quote |
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Cobimetinib (GDC-0973, XL518) is a potent, selective MEK inhibitor with IC50 of 4.2 nM for MEK1.
Cobimetinib (GDC-0973, XL518) shows excellent selectivity against mTOR, DNA-dependent protein kinase (DNA-PK), and a panel of more than 228 kinases.
Cobimetinib (GDC-0973, XL518) shows strong cellular potency in a broad panel of tumor types, particularly in BRAF or KRAS mutant cancer cell lines, triggers robust apoptosis and tumor growth inhibition in vivo combined with PI3K inhibitor GDC-0941.
| M.Wt | 531.31 | |
| Formula | C21H21F3IN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Methanone, [3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl][3-hydroxy-3-[(2S)-2-piperidinyl]-1-azetidinyl]- |
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1. Hoeflich KP, et al. Cancer Res. 2012 Jan 1;72(1):210-9.
2. Wong H, et al. Clin Cancer Res. 2012 Jun 1;18(11):3090-9.
3. Rice KD, et al. ACS Med Chem Lett. 2012 Apr 9;3(5):416-21.
4. Ribas A, et al. Lancet Oncol. 2014 Aug;15(9):954-65.
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