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Chemical Structure : AZD8330
CAS No.: 869357-68-6
Catalog No.: PC-42872Not For Human Use, Lab Use Only.
AZD8330 (ARRY-424704, ARRY-704) is a potent, selective, non-ATP competitive MEK1/2 inhibitor with IC50 of 7 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $378 | In stock | |
| 100 mg | Get quote |
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AZD8330 (ARRY-424704, ARRY-704) is a potent, selective, non-ATP competitive MEK1/2 inhibitor with IC50 of 7 nM.
AZD8330 displays no inhibitory activity against a panel of >200 other kinases.
AZD8330 demonstrates sub-nanomolar potency in mechanistic (pERK) and low to sub-nanomolar potency in functional (proliferation) assays in MEK1/2 inhibitor sensitive cell lines.
AZD8330 inhibits ERK phosphorylation and causes tumor growth inhibition in Calu-6 rat xenograft.
| M.Wt | 461.2267 | |
| Formula | C16H17FIN3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-Pyridinecarboxamide, 2-[(2-fluoro-4-iodophenyl)amino]-1,6-dihydro-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo- |
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1. Cohen RB, et al. Eur J Cancer. 2013 May;49(7):1521-9.
2. Baranski Z, et al. Genes Cancer. 2015 Nov;6(11-12):503-12.
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