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PD318088

Chemical Structure : PD318088

CAS No.: 391210-00-7

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PD318088 (PD 318088;PD-318088)

Catalog No.: PC-42877Not For Human Use, Lab Use Only.

PD318088 is a potent, non-ATP competitive, allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PD318088 is a potent, non-ATP competitive, allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site.

Physicochemical Properties

M.Wt 561.0891
Formula C16H13BrF3IN2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzamide, 5-bromo-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-

References

1. Han S, et al. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5467-73.

2. Zhang Y, et al. Mol Med Rep. 2014 Jan;9(1):83-90.

3. Ohren JF, et al. Nat Struct Mol Biol. 2004 Dec;11(12):1192-7.

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