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Chemical Structure : PD318088
CAS No.: 391210-00-7
Catalog No.: PC-42877Not For Human Use, Lab Use Only.
PD318088 is a potent, non-ATP competitive, allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PD318088 is a potent, non-ATP competitive, allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site.
| M.Wt | 561.0891 | |
| Formula | C16H13BrF3IN2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Benzamide, 5-bromo-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]- |
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1. Han S, et al. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5467-73.
2. Zhang Y, et al. Mol Med Rep. 2014 Jan;9(1):83-90.
3. Ohren JF, et al. Nat Struct Mol Biol. 2004 Dec;11(12):1192-7.
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