Catalog No.: PC-42870Not For Human Use, Lab Use Only.
BIX02189 is a potent, selective inhibitor of MEK5 catalytic activity with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity (IC50=59 nM), does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.
BIX02189 is a potent, selective inhibitor of MEK5 catalytic activity with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity (IC50=59 nM), does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.
BIX02189 blocks phosphorylation of ERK5, without affecting phosphorylation of ERK1/2 in sorbitol-stimulated HeLa cells, also inhibits transcriptional activation of MEF2C, a downstream substrate of the MEK5/ERK5 signaling cascade.
BIX02189 blocks ERK5 signaling and suppresses NGF-induced neurite outgrowth in PC12 cells.
