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Chemical Structure : EBI-1051
Catalog No.: PC-62537Not For Human Use, Lab Use Only.
EBI-1051 is a novel and orally efficacious MEK inhibitor with IC50 of 10.8 nM against MEK1, inhibits viability of colo-205 cells with IC50 of 4.7 nM.
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EBI-1051 is a novel and orally efficacious MEK inhibitor with IC50 of 10.8 nM against MEK1, inhibits viability of colo-205 cells with IC50 of 4.7 nM.
EBI-1051 shows superior potency in some cancer cell lines such as colon-205, A549 and MDA-MB-231 compared with AZD-6244.
| M.Wt | 504.228 | |
| Formula | C18H15F2IN2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lu B, et al. Bioorg Med Chem. 2018 Feb 1;26(3):581-589.
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