EBI-1051 |CAS:1801896-05-8 Probechem Biochemicals

Chemical Structure : EBI-1051

EBI-1051 (EBI1051)

Catalog No.: PC-62537Not For Human Use, Lab Use Only.

EBI-1051 is a novel and orally efficacious MEK inhibitor with IC50 of 10.8 nM against MEK1, inhibits viability of colo-205 cells with IC50 of 4.7 nM.

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Biological Activity

EBI-1051 is a novel and orally efficacious MEK inhibitor with IC50 of 10.8 nM against MEK1, inhibits viability of colo-205 cells with IC50 of 4.7 nM.
EBI-1051 shows superior potency in some cancer cell lines such as colon-205, A549 and MDA-MB-231 compared with AZD-6244.

Physicochemical Properties

M.Wt	504.228
Formula	C18H15F2IN2O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((1,3-Dihydroxypropan-2-yl)oxy)-7-fluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-5-carboxamide

References

1. Lu B, et al. Bioorg Med Chem. 2018 Feb 1;26(3):581-589.

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EBI-1051 (EBI1051)

Biological Activity

Physicochemical Properties

References

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