| Cat. No. |
Product Name |
Information |
| PC-42215 |
APS-2-79
KSR-MEK inhibitor
|
APS-2-79 is a small molecule compound that modulates KSR-dependent MAPK signalling by antagonizing RAF heterodimerization, and the conformational changes required for phosphorylation and activation of KSR-bound MEK (KSR2 IC50=120 nM). |
| PC-42489 |
PD0325901
MEK inhibitor
|
Mirdametinib (PD0325901) is a selective, non ATP-competitive MEK inhibitor with IC50 of 0.33 nM. |
| PC-44028 |
Refametinib
MEK1/2 inhibitor
|
Refametinib (BAY 86-97661, RDEA-119) is a potent, non-ATP-competitive, highly selective, allosteric inhibitor of MEK1/2 with IC50 of 19/47 nM respectively. |
| PC-45504 |
RO-5126766
Raf/MEK inhibitor
|
RO-5126766 (CH-5126766, Avutometinib, VS-6766) is a potent, first-in-class dual Raf/MEK inhibitor with IC50 of 56 nM/160 nM for C-Raf/MEK1. |
| PC-45828 |
PD-184352
MEK1/2 inhibitor
|
PD-184352 (CI-1040) is a potent, ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, displays 100-fold more selective for MEK1/2 than MEK5. |
| PC-42774 |
Trametinib
MEK1/2 inhibitor
|
Trametinib (GSK1120212, JTP-74057) is a potent and highly specific MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM. |
| PC-44036 |
RO4987655
MEK inhibitor
|
RO4987655 (CH4987655, RG-7167) is a potent and highly selective small-molecule MEK inhibitor with IC50 of 5.2 nM. |
| PC-45572 |
BI-847325
MEK/Aurora inhibitor
|
BI-847325 is a potent, ATP-competitive MEK/Aurora kinase inhibitor, inhibts human Aurora A (IC50=25 nM) and Aurora C (IC50=16 nM). |
| PC-45849 |
Selumetinib
MEK inhibitor
|
Selumetinib (ARRY-142886, AZD-6244) highly potent and selective, ATP-uncompetitive inhibitor of MEK1/2 with IC50/Ki of 14.1 nM/22.6 nM for MEK1. |
| PC-22721 |
Vacquinol-1 dihydrochloride
MKK4 activator
|
Vacquinol-1 (NSC 13316) dihydrochloride is a specific MKK4 (MAP2K4, MEK4) activator that induces vacuolization, induces ATP depletion in glioblastoma cells (IC50 = 3.14 uM) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells. |
| PC-21799 |
HRX-0233
MAP2K4 inhibitor
|
HRX-0233 (HRX0233) is a potent, selective MAP2K4 (MKK4) inhibitor, HRX-0233 is synergistic with RAS inhibitors in KRAS-mutant cancers. |
| PC-20654 |
DK2403
MAP2K7 (MEK7) inhibitor
|
DK2403 (DK-2403) is a highly potent, selective and covalent MAP2K7 (MEK7) inhibitor with IC50 of 10 nM, covalently engages the unique Cys218 residue within the active site. |
