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Chemical Structure : Trametinib
CAS No.: 871700-17-3
Catalog No.: PC-42774Not For Human Use, Lab Use Only.
Trametinib (GSK1120212, JTP-74057) is a potent and highly specific MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $58 | In stock | |
| 100 mg | $88 | In stock | |
| 500 mg | $198 | In stock | |
| 1 g | Get quote |
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Trametinib (GSK1120212, JTP-74057) is a potent and highly specific MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM.
Trametinib exhibits no inhibition on the kinase activities of c-Raf, B-Raf, ERK1/2.
| M.Wt | 615.3948 | |
| Formula | C26H23FIN5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Acetamide, N-[3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]- |
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1. Gilmartin AG, et al. Clin Cancer Res. 2011 Mar 1;17(5):989-1000.
2. Flaherty KT, et al. N Engl J Med. 2012 Nov 1;367(18):1694-703.
3. Yamaguchi T, et al. Int J Oncol, 2011, 39(1), 23-31.
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