Chemical Structure : Trametinib
CAS No.:
871700-17-3
Trametinib
(GSK1120212, JTP74057, JTP-74057)
Catalog No. : PC-42774Not For Human Use, Lab Use Only.
Trametinib (GSK1120212, JTP-74057) is a potent and highly specific MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM.
Packing Price Stock Quantity 50 mg $58 In stock 0 1 2 3 4 5 100 mg $88 In stock 0 1 2 3 4 5 500 mg $198 In stock 0 1 2 3 4 5 1 g Get quote 0 1 2 3 4 5
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4277401
Biological Activity
Trametinib (GSK1120212, JTP-74057) is a potent and highly specific MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM.
Physicochemical Properties
M.Wt
615.3948
Formula
C26H23FIN5O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Acetamide, N-[3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]-
References
1. Gilmartin AG, et al. Clin Cancer Res.
2. Flaherty KT, et al. N Engl J Med.
3. Yamaguchi T, et al. Int J Oncol,
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