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Trametinib

Chemical Structure : Trametinib

CAS No.: 871700-17-3

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Trametinib (GSK1120212, JTP74057, JTP-74057)

Catalog No.: PC-42774Not For Human Use, Lab Use Only.

Trametinib (GSK1120212, JTP-74057) is a potent and highly specific MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM.

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50 mg $58 In stock
100 mg $88 In stock
500 mg $198 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Trametinib (GSK1120212, JTP-74057) is a potent and highly specific MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM.
Trametinib  exhibits no inhibition on the kinase activities of c-Raf, B-Raf, ERK1/2.

Physicochemical Properties

M.Wt 615.3948
Formula C26H23FIN5O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Acetamide, N-[3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]-

References

1. Gilmartin AG, et al. Clin Cancer Res. 2011 Mar 1;17(5):989-1000.

2. Flaherty KT, et al. N Engl J Med. 2012 Nov 1;367(18):1694-703.

3. Yamaguchi T, et al. Int J Oncol, 2011, 39(1), 23-31.

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