Chemical Structure : RO4987655
CAS No.:
874101-00-5
RO4987655
(RO-4987655;RO 4987655;CH-4987655;CH4987655;CH 4987655;RG-7167)
Catalog No.: PC-44036Not For Human Use, Lab Use Only.
RO4987655 (CH4987655, RG-7167) is a potent and highly selective small-molecule MEK inhibitor with IC50 of 5.2 nM.
| Packing | Price | Stock | Quantity |
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $318 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | | Get quote | |
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Purity & Documentation Purity:
>98% (HPLC)
Select Batch:
Biological Activity
RO4987655 (CH4987655, RG-7167) is a potent and highly selective small-molecule MEK inhibitor with IC50 of 5.2 nM.
RO4987655 exhibits anti-proliferation IC50s of 1-10 nM for COLO205 (CRC, Braf V600E), HT29 (CRC, Braf V600E), QG56 (NSCLC, HrasQ61L), MIA PaCa-2 (Panc, Kras G12C) cell lines.
Physicochemical Properties
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M.Wt
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565.2816
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Formula
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C20H19F3IN3O5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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DMSO: ≥ 40 mg/mL
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Chemical Name/SMILES
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Benzamide, 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-5-[(tetrahydro-3-oxo-2H-1,2-oxazin-2-yl)methyl]-
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References
1. Isshiki Y, et al. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1795-801.
2. Lee L, et al. Clin Cancer Res. 2009 Dec 1;15(23):7368-74.
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