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Chemical Structure : RO4987655
CAS No.: 874101-00-5
Catalog No.: PC-44036Not For Human Use, Lab Use Only.
RO4987655 (CH4987655, RG-7167) is a potent and highly selective small-molecule MEK inhibitor with IC50 of 5.2 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $318 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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RO4987655 (CH4987655, RG-7167) is a potent and highly selective small-molecule MEK inhibitor with IC50 of 5.2 nM.
RO4987655 exhibits anti-proliferation IC50s of 1-10 nM for COLO205 (CRC, Braf V600E), HT29 (CRC, Braf V600E), QG56 (NSCLC, HrasQ61L), MIA PaCa-2 (Panc, Kras G12C) cell lines.
| M.Wt | 565.2816 | |
| Formula | C20H19F3IN3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 40 mg/mL |
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| Chemical Name/SMILES |
Benzamide, 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-5-[(tetrahydro-3-oxo-2H-1,2-oxazin-2-yl)methyl]- |
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1. Isshiki Y, et al. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1795-801.
2. Lee L, et al. Clin Cancer Res. 2009 Dec 1;15(23):7368-74.
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