Catalog No.: PC-44028Not For Human Use, Lab Use Only.
Refametinib (BAY 86-97661, RDEA-119) is a potent, non-ATP-competitive, highly selective, allosteric inhibitor of MEK1/2 with IC50 of 19/47 nM respectively.
Refametinib (BAY 86-97661, RDEA-119) is a potent, non-ATP-competitive, highly selective, allosteric inhibitor of MEK1/2 with IC50 of 19/47 nM respectively.
Refametinib inhibits anchorage-dependent growth of human cancer cell lines harboring the gain-of-function V600E BRAF mutant with GI50 of 67-89 nM.
Refametinib exhibits complete suppression of ERK phosphorylation at fully efficacious doses in mice and orally bioactive.
