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Chemical Structure : BI-847325
CAS No.: 1207293-36-4
Catalog No.: PC-45572Not For Human Use, Lab Use Only.
BI-847325 is a potent, ATP-competitive MEK/Aurora kinase inhibitor, inhibts human Aurora A (IC50=25 nM) and Aurora C (IC50=16 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $168 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | Get quote |
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BI-847325 is a potent, ATP-competitive MEK/Aurora kinase inhibitor, inhibts human Aurora A (IC50=25 nM) and Aurora C (IC50=16 nM).
BI-847325 also inhibits MEK1 (IC50=25 nM) and MEK2 (IC50=6 nM).
BI-847325 reduces expression of p-ERK and p-Histone 3 in multiple models of vemurafenib resistance.
BI-847325 decreases the expression of MEK and Mcl-1 and increases the expression of BIM.
BI-847325 is orally bioavailable.
| M.Wt | 464.5582 | |
| Formula | C29H28N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥36 mg/mL |
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| Chemical Name/SMILES |
2-Propynamide, 3-[3-[[[4-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indol-6-yl]-N-ethyl- |
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1. Phadke MS, et al. Mol Cancer Ther. 2015 Jun;14(6):1354-64.
2. Sini P, et al. Mol Cancer Ther. 2016 Oct;15(10):2388-2398.
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