G573 |CAS:22868-35-5 Probechem Biochemicals

Chemical Structure : G573

CAS No.: 22868-35-5

G573 (G 573, G-573)

Catalog No.: PC-62295Not For Human Use, Lab Use Only.

G 573 is a potent and selective, allosteric inhibitor of MEK with Ki of 0.3 nM.

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Biological Activity

G573 is a potent and selective, allosteric inhibitor of MEK with Ki of 0.3 nM.
G573 blocks MEK phosphorylation by BRAF(V600E), and stabilizes the RAF-MEK complex.
G573 inhibits the proliferation of A375 (BRAF V600E) with IC50 of 11 nM, 15-fold less potent for HCT116 (KRAS G13D).

Physicochemical Properties

M.Wt	228.68
Formula	C13H9ClN2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-Chlorophenyl)-1H-benzimidazole

References

1. Hatzivassiliou G, et al. Nature. 2013 Sep 12;501(7466):232-6.

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G573 (G 573, G-573)

Biological Activity

Physicochemical Properties

References

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