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Chemical Structure : G573
CAS No.: 22868-35-5
Catalog No.: PC-62295Not For Human Use, Lab Use Only.
G 573 is a potent and selective, allosteric inhibitor of MEK with Ki of 0.3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $358 | In stock | |
| 25 mg | $558 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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G573 is a potent and selective, allosteric inhibitor of MEK with Ki of 0.3 nM.
G573 blocks MEK phosphorylation by BRAF(V600E), and stabilizes the RAF-MEK complex.
G573 inhibits the proliferation of A375 (BRAF V600E) with IC50 of 11 nM, 15-fold less potent for HCT116 (KRAS G13D).
| M.Wt | 228.68 | |
| Formula | C13H9ClN2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-(3-Chlorophenyl)-1H-benzimidazole |
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1. Hatzivassiliou G, et al. Nature. 2013 Sep 12;501(7466):232-6.
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