E6201 |CAS:603987-35-5 Probechem Biochemicals

Chemical Structure : E6201

E6201 (ER-806201, ER806201, E 6201, E-6201)

Catalog No.: PC-62503Not For Human Use, Lab Use Only.

E 6201 (ER-806201) is a potent, selective, dual MEK1 and MEKK1 inhibitor, inhibits LPS-induced TNFα transcription with IC50 of 50 nM.

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Biological Activity

E 6201 (ER-806201) is a potent, selective, dual MEK1 and MEKK1 inhibitor, inhibits LPS-induced TNFα transcription with IC50 of 50 nM.
E 6201 does not suppress β-actin transcription at 3 uM and only slightly at 10 uM.
E 6201 inhibits MEK1-induced ERK2 phosphorylation with IC50 of 5.2 nM, MKK4-induced JNK phosphorylation with IC50 of 91 nM, and MKK6-induced p38α MAPK phosphorylation with IC50 of 19 nM.
E 6201 also inhibits MEKK1-induced phosphorylation of MEK1, MKK4, and MKK6 with IC50 of 31, 522, and 65 nM, respectively, has no effect on other MAPK family enzymes such as ERK2, JNKs, and p38 MAPK at 10 uM.E 6201 inhibits TNFα, IL-1β, IL-6, and IL-8 production from LPS-stimulated human PBMCs.

Physicochemical Properties

M.Wt	389.44
Formula	C21H27NO6
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,4R,5Z,8S,9S,11E)-14-(ethylamino)-8,9,16-trihydroxy-3,4-dimethyl-3,4,9,10-tetrahydro-1H-benzo[c][1]oxacyclotetradecine-1,7(8H)-dione

References

1. Goto M, et al. J Pharmacol Exp Ther. 2009 Nov;331(2):485-95.

E6201 (ER-806201, ER806201, E 6201, E-6201)

Biological Activity

Physicochemical Properties

References

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