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Chemical Structure : PD184161
CAS No.: 212631-67-9
Catalog No.: PC-60589Not For Human Use, Lab Use Only.
PD184161 is a potent, orally-active MEK1/2 inhibitor with IC50 of 10-100 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $158 | In stock | |
| 25 mg | $278 | In stock | |
| 50 mg | $468 | In stock | |
| 100 mg | Get quote |
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PD184161 is a potent, orally-active MEK1/2 inhibitor with IC50 of 10-100 nM.
PD184161 inhibits HCC cell proliferation and induced apoptosis at concentrations of > or = 1.0 uM, significantly suppresses tumor engraftment and initial growth in tumor xenografts.
PD184161 also blocks AngII-driven HIF-1α protein in vascular smooth muscle cells, increases HIF-1α binding to von Hippel-Lindau tumor suppressor protein, blocks mitochondrial ROS production and cellular ATP levels.
| M.Wt | 557.6 | |
| Formula | C17H13BrClF2IN2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-bromo-2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluoro-benzamide |
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1. Klein PJ, et al. Neoplasia. 2006 Jan;8(1):1-8.
2. Yip-Schneider MT, et al. J Pharmacol Exp Ther. 2009 Jun;329(3):1063-70.
3. Mazharian A, et al. Exp Hematol. 2009 Oct;37(10):1238-1249.e5.
4. Jalouli M, et al. Mol Pharmacol. 2017 Nov;92(5):510-518.
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