| Cat. No. |
Product Name |
Information |
| PC-73145 |
GDC-0623
MEK1 inhibitor
|
GDC-0623 (RG 7421) is a potent, selective, ATP-uncompetitive inhibitor of MEK1 (Ki=0.13 nM). |
| PC-43379 |
Cobimetinib racemate
|
Cobimetinib racemate is the racemate form of Cobimetinib (GDC-0973, XL518), which is a potent, highly selective inhibitor of MEK1/2.. |
| PC-42869 |
BIX02188
|
BIX02188 is a potent, selective inhibitor of MEK5 catalytic activity with IC50 of 4.3 nM, wekaly inhibits ERK5 catalytic activity (IC50=810 nM) and does not inhibits closely related kinases MEK1, MEK2, ERK2, and JNK2. |
| PC-63100 |
WX-554
|
WX-554 is an oral, small molecule allosteric inhibitor targeting mitogen-activated protein kinase kinase (MEK1 and MEK2) with an estimated IC50 of 4.7 and 10.7 nM, respectively. |
| PC-61420 |
Etacrynic acid
|
A loop diuretic used to treat high blood pressure and the swelling, a novel ligand and inhibitor of MAP2K6 kinase that inhibits MAP2K6 in part through alkylation of a nonconserved cysteine residue. |
| PC-42462 |
Refametinib R enantiomer
|
The R enantiomer of Refametinib, a potent, non–ATP-competitive, highly selective, allosteric inhibitor of MEK1/2 with IC50 of 19/47 nM respectively.. |
| PC-42775 |
Trametinib DMSO solvate
|
A potent and highly specific MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM. |
