| Cat. No. |
Product Name |
Information |
| PC-45849 |
Selumetinib
MEK inhibitor
|
Selumetinib (ARRY-142886, AZD-6244) highly potent and selective, ATP-uncompetitive inhibitor of MEK1/2 with IC50/Ki of 14.1 nM/22.6 nM for MEK1. |
| PC-25083 |
Polfurmetinib
MEK inhibitor
|
Polfurmetinib (Compound II) is a potent, selective mitogen activated protein kinase (MEK) inhibitor, displays an IC50 of 8 nM in human malignant melanoma A375 cells, inhibits ERK1/2 (Thr202/Tyr204) phosphorylation with IC50 of 2 nM. |
| PC-25048 |
Envometinib
MEK inhibitor
|
Envometinib (Compound 274) is a potent, selective dual MEK1/2 inhibitor, inhibits both pERK and pMEK in RAS mutant and NF-I loss of function (LoF) tumor models. |
| PC-24941 |
MKK4 inhibitor 39
MKK4 inhibitor
|
MKK4 inhibitor 39 is a potent, selective inhibitor of MKK (MEK4 or MAP2K4) with IC50 of 78 nM, 37-fold selective over RSK4 and high kinome selectivity. |
| PC-24109 |
Atebimetinib
MEK inhibitor
|
Atebimetinib is a potent, selective MEK tyrosine kinase inhibitor with antineoplastic activity. |
| PC-23993 |
Sinensetin
MKK6 inhibitor
|
Sinensetin is a methylated flavonoid found in fruits that has strong anti-vascular and anti-inflammatory properties, sinensetin is a specific inhibitor of MKK6 with KD of 62 uM. |
| PC-22721 |
Vacquinol-1 dihydrochloride
MKK4 activator
|
Vacquinol-1 (NSC 13316) dihydrochloride is a specific MKK4 (MAP2K4, MEK4) activator that induces vacuolization, induces ATP depletion in glioblastoma cells (IC50 = 3.14 uM) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells. |
| PC-43379 |
Cobimetinib racemate
|
Cobimetinib racemate is the racemate form of Cobimetinib (GDC-0973, XL518), which is a potent, highly selective inhibitor of MEK1/2.. |
| PC-42869 |
BIX02188
|
BIX02188 is a potent, selective inhibitor of MEK5 catalytic activity with IC50 of 4.3 nM, wekaly inhibits ERK5 catalytic activity (IC50=810 nM) and does not inhibits closely related kinases MEK1, MEK2, ERK2, and JNK2. |
| PC-63100 |
WX-554
|
WX-554 is an oral, small molecule allosteric inhibitor targeting mitogen-activated protein kinase kinase (MEK1 and MEK2) with an estimated IC50 of 4.7 and 10.7 nM, respectively. |
| PC-61420 |
Etacrynic acid
|
A loop diuretic used to treat high blood pressure and the swelling, a novel ligand and inhibitor of MAP2K6 kinase that inhibits MAP2K6 in part through alkylation of a nonconserved cysteine residue. |
| PC-42462 |
Refametinib R enantiomer
|
The R enantiomer of Refametinib, a potent, non–ATP-competitive, highly selective, allosteric inhibitor of MEK1/2 with IC50 of 19/47 nM respectively.. |
