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Chemical Structure : Vacquinol-1 dihydrochloride
Catalog No.: PC-22721Not For Human Use, Lab Use Only.
Vacquinol-1 (NSC 13316) dihydrochloride is a specific MKK4 (MAP2K4, MEK4) activator that induces vacuolization, induces ATP depletion in glioblastoma cells (IC50 = 3.14 uM) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells.
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Vacquinol-1 (NSC 13316) dihydrochloride is a specific MKK4 (MAP2K4, MEK4) activator that induces vacuolization, induces ATP depletion in glioblastoma cells (IC50 = 3.14 uM) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells.
Vacquinol-1 induces rapid and specific cell death of glioma cells via membrane ruffling, cell rounding, massive macropinocytic vacuole accumulation, ATP depletion, and cytoplasmic membrane rupture.
Vacquinol-1 shows good brain penetrance and excellent pharmacokinetics; orally bioactive.
| M.Wt | 425.78 | |
| Formula | C21H23Cl3N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kitambi SS, et al. Cell. 2014 Apr 10;157(2):313-28.
2. Hammarström LG, et al. J Med Chem. 2016 Sep 22;59(18):8577-92.
3. Sander P, et al. Oncotarget. 2017 May 23;8(21):35124-35137.
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