Chemical Structure : Vacquinol-1 dihydrochloride
CAS No.:
2309312-85-2
Vacquinol-1 dihydrochloride
(NSC13316 dihydrochloride)
Catalog No.: PC-22721Not For Human Use, Lab Use Only.
Vacquinol-1 (NSC 13316) dihydrochloride is a specific MKK4 (MAP2K4, MEK4) activator that induces vacuolization, induces ATP depletion in glioblastoma cells (IC50 = 3.14 uM) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Vacquinol-1 (NSC 13316) dihydrochloride is a specific MKK4 (MAP2K4, MEK4) activator that induces vacuolization, induces ATP depletion in glioblastoma cells (IC50 = 3.14 uM) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells.
Vacquinol-1 induces rapid and specific cell death of glioma cells via membrane ruffling, cell rounding, massive macropinocytic vacuole accumulation, ATP depletion, and cytoplasmic membrane rupture.
Vacquinol-1 shows good brain penetrance and excellent pharmacokinetics; orally bioactive.
Physicochemical Properties
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M.Wt
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425.78
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Formula
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C21H23Cl3N2O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-Quinolinemethanol, 2-(4-chlorophenyl)-α-2-piperidinyl-, hydrochloride (1:2)
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References
1. Kitambi SS, et al. Cell. 2014 Apr 10;157(2):313-28.
2. Hammarström LG, et al. J Med Chem. 2016 Sep 22;59(18):8577-92.
3. Sander P, et al. Oncotarget. 2017 May 23;8(21):35124-35137.
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