Polfurmetinib | MEK inhibitor | Probechem Biochemicals

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Chemical Structure : Polfurmetinib

Polfurmetinib (MEK-IN-6)

Catalog No.: PC-25083Not For Human Use, Lab Use Only.

Polfurmetinib (Compound II) is a potent, selective mitogen activated protein kinase (MEK) inhibitor, displays an IC50 of 8 nM in human malignant melanoma A375 cells, inhibits ERK1/2 (Thr202/Tyr204) phosphorylation with IC50 of 2 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	393.43
Formula	C18H20FN3O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione

References

1. Patent WO2022208391 A1.

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Polfurmetinib (MEK-IN-6)

Biological Activity

Physicochemical Properties

References

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