Chemical Structure : Etacrynic acid
CAS No.:
58-54-8
Etacrynic acid
(Edecrin)
Catalog No.: PC-61420Not For Human Use, Lab Use Only.
A loop diuretic used to treat high blood pressure and the swelling, a novel ligand and inhibitor of MAP2K6 kinase that inhibits MAP2K6 in part through alkylation of a nonconserved cysteine residue.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
A loop diuretic used to treat high blood pressure and the swelling, a novel ligand and inhibitor of MAP2K6 kinase that inhibits MAP2K6 in part through alkylation of a nonconserved cysteine residue; shows anticancer activity, and also is a potent inhibitor of glutathione S-transferase; shows antitumor effects and may enhance the cytotoxicity of chemotherapeutic agents by binding to glutathione and inhibiting WNT signaling.
Other Indication
Phase 2 Clinical
Physicochemical Properties
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M.Wt
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303.135
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Formula
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C13H12Cl2O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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Acetic acid, [2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy]- (9CI)
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References
1. Chan AI, et al. J Am Chem Soc. 2017 Aug 2;139(30):10192-10195.
2. Wang R, et al. Clin Cancer Res. 2012 Dec 15;18(24):6690-701.
3. Bryant ZE, et al. Bioorg Med Chem Lett. 2011 Feb 1;21(3):912-5.
4. Liu B, et al. Oncotarget. 2016 Sep 6;7(36):58038-58050.
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