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Chemical Structure : Etacrynic acid
Catalog No.: PC-61420Not For Human Use, Lab Use Only.
A loop diuretic used to treat high blood pressure and the swelling, a novel ligand and inhibitor of MAP2K6 kinase that inhibits MAP2K6 in part through alkylation of a nonconserved cysteine residue.
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A loop diuretic used to treat high blood pressure and the swelling, a novel ligand and inhibitor of MAP2K6 kinase that inhibits MAP2K6 in part through alkylation of a nonconserved cysteine residue; shows anticancer activity, and also is a potent inhibitor of glutathione S-transferase; shows antitumor effects and may enhance the cytotoxicity of chemotherapeutic agents by binding to glutathione and inhibiting WNT signaling.
Other Indication
Phase 2 Clinical
| M.Wt | 303.135 | |
| Formula | C13H12Cl2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chan AI, et al. J Am Chem Soc. 2017 Aug 2;139(30):10192-10195.
2. Wang R, et al. Clin Cancer Res. 2012 Dec 15;18(24):6690-701.
3. Bryant ZE, et al. Bioorg Med Chem Lett. 2011 Feb 1;21(3):912-5.
4. Liu B, et al. Oncotarget. 2016 Sep 6;7(36):58038-58050.
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