WX-554 | Probechem Biochemicals

Chemical Structure : WX-554

WX-554 (WX554)

Catalog No.: PC-63100Not For Human Use, Lab Use Only.

WX-554 is an oral, small molecule allosteric inhibitor targeting mitogen-activated protein kinase kinase (MEK1 and MEK2) with an estimated IC50 of 4.7 and 10.7 nM, respectively.

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Biological Activity

WX-554 is an oral, small molecule allosteric inhibitor targeting mitogen-activated protein kinase kinase (MEK1 and MEK2) with an estimated IC50 of 4.7 and 10.7 nM, respectively; exhibits marked synergistic growth inhibition in vitro, which is associated with increased cytotoxicity and enhanced inhibition of ERK and S6 phosphorylation.

Solid Tumors

Phase 1 Discontinued

Physicochemical Properties

M.Wt
Formula
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

References

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WX-554 (WX554)

Biological Activity

Physicochemical Properties

References

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