Refametinib R enantiomer |CAS:923032-38-6 Probechem Biochemicals

Chemical Structure : Refametinib R enantiomer

Catalog No.: PC-42462Not For Human Use, Lab Use Only.

The R enantiomer of Refametinib, a potent, non–ATP-competitive, highly selective, allosteric inhibitor of MEK1/2 with IC50 of 19/47 nM respectively..

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

The R enantiomer of Refametinib, a potent, non–ATP-competitive, highly selective, allosteric inhibitor of MEK1/2 with IC50 of 19/47 nM respectively.

M.Wt	572.3372
Formula	C19H20F3IN2O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO
Chemical Name/SMILES	Cyclopropanesulfonamide, N-[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2R)-2,3-dihydroxypropyl]-

1. Iverson C, et al. Cancer Res. 2009 Sep 1;69(17):6839-47.

2. Chang Q, et al. BMC Cancer. 2010 Sep 28;10:515.

3. Schmieder R, et al. Neoplasia. 2013 Oct;15(10):1161-71.