MKK4 inhibitor 39

Chemical Structure : MKK4 inhibitor 39

Catalog No.: PC-24941Not For Human Use, Lab Use Only.

MKK4 inhibitor 39 is a potent, selective inhibitor of MKK (MEK4 or MAP2K4) with IC50 of 78 nM, 37-fold selective over RSK4 and high kinome selectivity.

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Biological Activity

MKK4 inhibitor 39 is a potent, selective inhibitor of MKK (MEK4 or MAP2K4) with IC50 of 78 nM, 37-fold selective over RSK4 and high kinome selectivity.
MKK4 inhibitor 39 exhibits a selectivity score of 0.009 at 1 μM.
MKK4 inhibitor 39 exhibits robust target engagement in CETSA analysis.

Physicochemical Properties

M.Wt	353.36
Formula	C18H16FN5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((1-cyclopropyl-4-methyl-3-oxo-1,2,3,4-tetrahydropyrido[3,4-b]pyrazin-7-yl)amino)-3-fluoro-2-hydroxybenzonitrile

References

1. Leon Katzengruber, et al. J Med Chem. 2025 Jul 11. doi: 10.1021/acs.jmedchem.5c00919.

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