Selumetinib (ARRY-142886, AZD6244)

Chemical Structure : Selumetinib

CAS No.: 606143-52-6

Catalog No.: PC-45849Not For Human Use, Lab Use Only.

Selumetinib (ARRY-142886, AZD-6244) highly potent and selective, ATP-uncompetitive inhibitor of MEK1/2 with IC50/Ki of 14.1 nM/22.6 nM for MEK1.

Packing	Price	Stock
50 mg	$58	In stock
100 mg	$88	In stock
250 mg	$138	In stock
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Biological Activity

Selumetinib (ARRY-142886, AZD6244) highly potent and selective, ATP-uncompetitive inhibitor of MEK1/2 with IC50/Ki of 14.1 nM/22.6 nM for MEK1.
Selumetinib (ARRY-142886, AZD-6244) shows no activity against other 40 serine/threonine and tyrosine kinases.
Selumetinib (ARRY-142886, AZD-6244) inhibits cellular ERK1/2 phosphorylation (IC50<40 nM), suppresses growth inhibition of several cell lines containing B-Raf and Ras mutations (IC50=59-473 nM).
Selumetinib (ARRY-142886, AZD-6244) causes growth of HT-29 xenograft tumors in nude mice.

Physicochemical Properties

M.Wt	457.6814
Formula	C17H15BrClFN4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 34 mg/mL
Chemical Name/SMILES	1H-Benzimidazole-6-carboxamide, 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-

References

1. Huynh H, et al. Mol Cancer Ther. 2007 Jan;6(1):138-46.

2. Yeh TC, et al. Clin Cancer Res. 2007 Mar 1;13(5):1576-83.

3. Davies BR, et al. Mol Cancer Ther. 2007 Aug;6(8):2209-19.