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Chemical Structure : TAK-733
CAS No.: 1035555-63-5
Catalog No.: PC-43541Not For Human Use, Lab Use Only.
TAK-733 (TAK733,TAK 733) is a potent, selective, allosteric inhibitor of MEK with IC50 of 3.2 nM (MEK1).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 25 mg | $328 | In stock | |
| 100 mg | $798 | In stock | |
| 500 mg | Get quote |
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TAK-733 (TAK733,TAK 733) is a potent, selective, allosteric inhibitor of MEK with IC50 of 3.2 nM (MEK1).
TAK-733 shows selectivity for MEK1 over a panel of 18 kinases, receptors, and ion channels at 1 uM.
TAK-733 inhibits ERK phosphorylation in vitro with EC50 of 1.9 nM, also inhibits proliferation of A375 and COLO 205 cells with IC50 of 3.1 nM and 2.1 nM, respectively.
TAK-733 demonstrates antitumor activity in multiple mouse xenograft models.
| M.Wt | 504.2267 | |
| Formula | C17H15F2IN4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 33 mg/mL |
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| Chemical Name/SMILES |
Pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione, 3-[(2R)-2,3-dihydroxypropyl]-6-fluoro-5-[(2-fluoro-4-iodophenyl)amino]-8-methyl- |
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1. Dong Q, et al. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1315-9.
2. von Euw E, et al. Mol Cancer. 2012 Apr 19;11:22.
3. Dahlman KB, et al. Cancer Discov. 2012 Sep;2(9):791-7.
4. Micel LN, et al. Mol Cancer Ther. 2015 Feb;14(2):317-25.
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