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Chemical Structure : MKK7-COV-9
Catalog No.: PC-35805Not For Human Use, Lab Use Only.
MKK7-COV-9 (MKK7 Covalen inhibitor 9) is a potent, selective, covalent MKK7 inhibitor, displays >1,000-fold selectivity over MKK4.
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MKK7-COV-9 (MKK7 Covalen inhibitor 9) is a potent, selective, covalent MKK7 inhibitor, displays >1,000-fold selectivity over MKK4.
MKK7-COV-9 displays remarkable selectivity against a kinome panel of 76 kinases.
MKK7-COV-9 inhibits the CD86+ response in primary mouse B cells in response to LPS stimulation (EC50=4.9 uM).
MKK7-COV-9 has half-lives >40 min in dog and rat, and significantly improved stability in human and monkey liver microsomes.
MKK7-COV-9 is not cytotoxic to a panel of human cell lines.
| M.Wt | 320.352 | |
| Formula | C18H16N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shraga A, et al. Cell Chem Biol. 2018 Oct 24. pii: S2451-9456(18)30344-1.
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