MKK7-COV-9 | Probechem Biochemicals

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Chemical Structure : MKK7-COV-9

MKK7-COV-9 (MKK7 Covalen inhibitor 9)

Catalog No.: PC-35805Not For Human Use, Lab Use Only.

MKK7-COV-9 (MKK7 Covalen inhibitor 9) is a potent, selective, covalent MKK7 inhibitor, displays >1,000-fold selectivity over MKK4.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

MKK7-COV-9 (MKK7 Covalen inhibitor 9) is a potent, selective, covalent MKK7 inhibitor, displays >1,000-fold selectivity over MKK4.
MKK7-COV-9 displays remarkable selectivity against a kinome panel of 76 kinases.
MKK7-COV-9 inhibits the CD86+ response in primary mouse B cells in response to LPS stimulation (EC50=4.9 uM).
MKK7-COV-9 has half-lives >40 min in dog and rat, and significantly improved stability in human and monkey liver microsomes.
MKK7-COV-9 is not cytotoxic to a panel of human cell lines.

Physicochemical Properties

M.Wt	320.352
Formula	C18H16N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-acrylamido-5-(1H-indazol-3-yl)-N-methylbenzamide

References

1. Shraga A, et al. Cell Chem Biol. 2018 Oct 24. pii: S2451-9456(18)30344-1.

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MKK7-COV-9 (MKK7 Covalen inhibitor 9)

Biological Activity

Physicochemical Properties

References

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