MAP855 | MEK1/2 inhibitor | Probechem Biochemicals

Chemical Structure : MAP855

MAP855 (MAP-855)

Catalog No.: PC-72697Not For Human Use, Lab Use Only.

MAP855 (MAP-855) is a highly potent, selective, ATP-competitive MEK1/2 inhibitor (pERK IC50=5 nM) with equipotent inhibition of WT and mutant MEK1/2.

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Biological Activity

MAP855 (MAP-855) is a highly potent, selective, ATP-competitive MEK1/2 inhibitor (pERK IC50=5 nM) with equipotent inhibition of WT and mutant MEK1/2.

Physicochemical Properties

M.Wt	564.978
Formula	C28H23ClF2N6O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((3S,4S)-4-(8-(2-chloro-4-(pyrimidin-2-yloxy)phenyl)-7-fluoro-2-methyl-1H-imidazo[4,5-c]quinolin-1-yl)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one

References

1. Poddutoori R, et al. Med Chem. 2022 Feb 23.

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MAP855 (MAP-855)

Biological Activity

Physicochemical Properties

References

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