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MAP855

Chemical Structure : MAP855

CAS No.: 1660107-77-6

MAP855 (MAP-855)

Catalog No.: PC-72697Not For Human Use, Lab Use Only.

MAP855 (MAP-855) is a highly potent, selective, ATP-competitive MEK1/2 inhibitor (pERK IC50=5 nM) with equipotent inhibition of WT and mutant MEK1/2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MAP855 (MAP-855) is a highly potent, selective, ATP-competitive MEK1/2 inhibitor (pERK IC50=5 nM) with equipotent inhibition of WT and mutant MEK1/2.

    Physicochemical Properties

    M.Wt 564.978
    Formula C28H23ClF2N6O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    1-((3S,4S)-4-(8-(2-chloro-4-(pyrimidin-2-yloxy)phenyl)-7-fluoro-2-methyl-1H-imidazo[4,5-c]quinolin-1-yl)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one

    References

    1. Poddutoori R, et al. Med Chem. 2022 Feb 23.

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