Catalog No.: PC-73276Not For Human Use, Lab Use Only.
INR119 is a small molecule allosteric MAPKK (MAP2K, MEK1/2) inhibitor, binds fission yeast homologue Wis1 near C458 and protects Wis1 from inactivation by low levels of H2O2 in vitro.
INR119 is a small molecule allosteric MAPKK (MAP2K, MEK1/2) inhibitor, binds fission yeast homologue Wis1 near C458 and protects Wis1 from inactivation by low levels of H2O2 in vitro.
INR119 pretreatment strongly potentiates the Wis1 response to low H2O2 in vivo.
Phosphorylation of Sty1 depends entirely on activated Wis1, and the INR119-induced enhancement of Sty1 pathway activation upon H2O2 stress requires the upstream activation of Wis1 through the MAPKKKs.
Physicochemical Properties
M.Wt
281.311
Formula
C17H15NO3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2-(2-amino-3-ethoxyphenyl)-4H-chromen-4-one
References
1. Sjölander JJ, et al. Mol Cell Biol. 2020 Mar 16;40(7):e00346-19.
2. Redwan IN, et al. Eur J Med Chem 85:127–138.
3. Otręba M, et al. Life (Basel). 2021 Mar 31;11(4):297.
