Chemical Structure : Forvisirvat
CAS No.:
2135638-06-9
Forvisirvat
(SP-624, SP624)
Catalog No.: PC-25052Not For Human Use, Lab Use Only.
Forvisirvat (SP‐624) is a selective, orally active sirtuin 6 (SIRT6) activator.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Forvisirvat (SP‐624) is a selective, orally active sirtuin 6 (SIRT6) activator.
SP‐624 activates SIRT6 deacetylation of histone peptides and deacetylation of H3K9 and H3K18 in intact nucleosomes.
SP‐624 is active in multiple animal models used to predict efficacy for depression in humans, including tests in adrenocorticotropic hormone‐treated mice and olfactory bulbectomized rats.
SP‐624 also prevents cognitive deficits induced by scopolamine (anticholinergic) or phencyclidine (N‐methyl‐D‐aspartate antagonist) in the novel object recognition test and suppressed excessive cytokine release in animal models.
Physicochemical Properties
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M.Wt
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404.80
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Formula
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C19H17ClN2O6
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2S,6'R)-7-chloro-2',4-dimethoxy-6'-methyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-3H-spiro[benzofuran-2,1'-cyclohexan]-2'-ene-3,4'-dione
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References
1. Greg Rigdon, et al. Clin Pharmacol Drug Dev. 2025 Jan;14(1):18-25.
2. Patent WO2024168215 A1.
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