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Cat. No. Product Name CAS No. Information


2275619-53-7 MDL-800 (MDL800) is a first-in-class, selective, cellular active SIRT6 allosteric activator, increases SIRT6 deacetylation activity with EC50 of 10.3 uM in RHKK-ac-AMC and FDL assays.


1848251-24-0 SirReal2 (MZ25) is a novel potent, selective Sirt2 inhibitor with IC50 of 0.435 uM.

SIRT6 activator 12q

2601734-99-8 SIRT6 activator 12q (Compound 12q) is a potent, selective SIRT6 activator with EC1.5 value of 0.58 μM and EC50 value of 5.35 μM against SIRT6-dependent peptide deacetylation in FLUOR DE LYS assay.

SIRT6 activator CL5D

2488745-53-3 SIRT6 activator CL5D is a novel small-molecule activator of SIRT6 deacetylation, stimulates 4-fold activation of SIRT6 (1 uM) against H3K9ac (20 uM) at 3 uM.


304896-28-4 AGK2 is a cell-permeable, selective inhibitor of SIRT2 with IC50 of 3.2 uM, shows minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.


1224713-90-9 4'-bromo-resveratrol (4'-BR) is a dual small molecule inhibitor of SIRT1 and SIRT3, inhibits melanoma cell growth through mitochondrial metabolic reprogramming.

SIRT7 inhibitor 97491

1807758-81-1 SIRT7 inhibitor 97491 is a novel specific inhibitor of SIRT7 with IC50 of 0.325 uM, reduces deacetylase activity of SIRT7 in a dose-dependent manner.

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